Pharmaceutical Drug Targets and Diseases: Difference between revisions

David Canner (talk | contribs)
No edit summary
David Canner (talk | contribs)
No edit summary
Line 6: Line 6:


**Alzheimer’s Disease
**Alzheimer’s Disease
***[[Acetylcholine]]
***See: [[Alzheimer's Disease]]
***[[Acetylcholinesterase]]
***[[2ace|Acetylcholinesterase from Torpedo Californica]]
***[[African Malaria Mosquito Acetylcholinesterase]]
***[[SANDBOX138|Human APP Intracellular Domain Complex with Fe65-PTB2]]
***[[Flexibility of aromatic residues in acetylcholinesterase|Aromatic Residue Flexibility in AChE]]
***[[Beta Amyloid]]
***[[Acetylcholine binding protein]]  (AChBP)
***[[Butyrylcholinesterase]] (BChE)
***Drug Compounds & Substrates
****[[AChE_bivalent_inhibitors|Bivalent Inhibitors of Acetylcholinesterase]]
****[[AChE_bivalent_inhibitors_%28Part_II%29|Bivalent Inhibitors of Acetylcholinesterase, Part II]]
****[[AChE_inhibitors_and_substrates|Inhibitors and Substrates of Acetylcholinesterase]]
****[[ AChE_inhibitors_and_substrates_%28Part_II%29|Inhibitors and Substrates of Acetylcholinesterase, Part II]]
****[[ AChE_inhibitors_and_substrates_%28Part_III%29|Inhibitors and Substrates of Acetylcholinesterase, Part III]]
****Specific Examples:
*****[[1eve|Aricept Complexed with Acetylcholinesterase]]
*****[[2dfp|DFP (Aged) Complexed with Acetylcholinesterase]]
*****[[1ax9|Edrophonium Complexed with Acetylcholinesterase]] or [[2ack|Here]]
*****[[2j3q|Fluorophore Thioflavin T Complexed with Acetylcholinesterase]]
*****[[1dx6|Galanthamine Complexed with Acetylcholinesterase]]
*****[[1vot|Huperzine A Complexed with Acetylcholinesterase]]
*****[[1w6r|Iminium Galanthamine Derivative bound to Acetylcholinesterase]] or [[1w4l|Here]], or [[1w76|Here]].
*****[[1gqs|NAP Complexed with Acetylcholinesterase]]
*****[[1vxr|O-tthylmethylphosphonylated Acetylcholinesterase]]
*****[[2wfz|Soman Complexed with Acetylcholinesterase]] or [[2wg0|Here]], or [[2wg1|Here]], or [[1cfj|Here]], or [[1som|Here]].
*****[[1acj|Tacrine Complexed with Acetylcholinesterase]]
**** Bivalent Inhibitors
*****[[1u65|Anticancer Prodrug CPT-11 Complexed with Acetylcholinesterase]]
*****[[1eve|Aricept Complexed with Acetylcholinesterase]]
*****[[1w4l|Bis-Acting Galanthamine Derivative Complexed with Acetylcholinesterase]], or [[1w76|Here]], or [[1w6r|Here]]
*****[[2cmf|Bis-Tacrine Derivative Complexed with Acetylcholinesterase]] or [[2ckm|Here]] or [[1odc|Here]]
*****[[1acl|Bisquaternary Decamethonium Complexed with Acetylcholinesterase]]
*****[[1e3q|BW284C51 Complexed with Acetylcholinesterase]]
*****[[1zgb|Hupyridone Derivative Complexed with Acetylcholinesterase]], or [[1zgc|Here]], or [[1h22|Here]], or [[1h23|Here]]
*****[[1ut6|N-9-(1',2',3',4'-TETRAHYDROACRIDINYL)-1,8-DIAMINOOCTANE Complexed with Acetylcholinesterase]]
*****[[1jjb|PEG-SH Complexed with Acetylcholinesterase]]
***[[Gamma-Secratase]]
***Glutamate Receptor
****[[Glutamate receptor (GluA2)]]
****[[Molecular_Playground/Glutamate_Receptor|Glutamate Receptor]]


**Anemia
**Anemia

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

David Canner, Thomas J. Stout, Eran Hodis, Wayne Decatur, Alexander Berchansky