2qrn: Difference between revisions

Revision as of 19:41, 21 February 2008

Human Deoxycytidine kinase dCMP, UDP, Mg ion product complex

OverviewOverview

Human deoxycytidine kinase (dCK) is involved in the nucleotide-biosynthesis salvage pathway and has also been shown to phosphorylate several antitumor and antiviral prodrugs. The structures of dCK alone and the dead-end complex of dCK with substrate nucleoside and product ADP or UDP have previously been reported; however, there is currently no structure available for a substrate or product complex. Here, the structures of dCK complexes with the products dCMP, UDP and Mg2+ ion, and with dAMP, UDP and Mg2+ ion are reported. Structural comparisons show that the product complexes with UDP and a dead-end complex with substrate and UDP have similar active-site conformations.

About this StructureAbout this Structure

2QRN is a Single protein structure of sequence from Homo sapiens with , and as ligands. Active as Deoxycytidine kinase, with EC number 2.7.1.74 Full crystallographic information is available from OCA.

ReferenceReference

Structures of human deoxycytidine kinase product complexes., Soriano EV, Clark VC, Ealick SE, Acta Crystallogr D Biol Crystallogr. 2007 Dec;63(Pt 12):1201-7. Epub 2007, Nov 16. PMID:18084067

Page seeded by OCA on Thu Feb 21 18:41:45 2008

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OCA

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 ==Overview==
-Human deoxycytidine kinase (dCK) is involved in the, nucleotide-biosynthesis salvage pathway and has also been shown to, phosphorylate several antitumor and antiviral prodrugs. The structures of, dCK alone and the dead-end complex of dCK with substrate nucleoside and, product ADP or UDP have previously been reported; however, there is, currently no structure available for a substrate or product complex. Here, the structures of dCK complexes with the products dCMP, UDP and Mg(2+), ion, and with dAMP, UDP and Mg(2+) ion are reported. Structural, comparisons show that the product complexes with UDP and a dead-end, complex with substrate and UDP have similar active-site conformations.
+Human deoxycytidine kinase (dCK) is involved in the nucleotide-biosynthesis salvage pathway and has also been shown to phosphorylate several antitumor and antiviral prodrugs. The structures of dCK alone and the dead-end complex of dCK with substrate nucleoside and product ADP or UDP have previously been reported; however, there is currently no structure available for a substrate or product complex. Here, the structures of dCK complexes with the products dCMP, UDP and Mg2+ ion, and with dAMP, UDP and Mg2+ ion are reported. Structural comparisons show that the product complexes with UDP and a dead-end complex with substrate and UDP have similar active-site conformations.
 ==About this Structure==
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 [[Category: Homo sapiens]]
 [[Category: Single protein]]
-[[Category: Ealick, S.E.]]
+[[Category: Ealick, S E.]]
-[[Category: Soriano, E.V.]]
+[[Category: Soriano, E V.]]
 [[Category: DCM]]
 [[Category: MG]]
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 [[Category: uridine diphosphate]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 23 11:03:32 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 18:41:45 2008''