Sandbox 250: Difference between revisions
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<applet load='1fss' size='300' frame='true' align='right' scene='Sandbox_250/Ache_fas2/ | |||
<applet load='1fss' size='300' frame='true' align='right' scene='Sandbox_250/Ache_fas2/2' caption='AChE/FAS-II' /> | |||
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FAS-II <scene name='Sandbox/Ache_1fss/1'>amino acids 1-61</scene> were illustrated in an alpha carbon backbone. The alpha carbon backbone of FAS-II has 4 beta sheets forming three loops or fingers. | FAS-II <scene name='Sandbox/Ache_1fss/1'>amino acids 1-61</scene> were illustrated in an alpha carbon backbone. The alpha carbon backbone of FAS-II has 4 beta sheets forming three loops or fingers. | ||
The <scene name=' | The residues <scene name='Sandbox_250/Ache_fas2/3'>Thr8, Met33, Arg27 and Val34</scene> are present on two loops of the toxin FAS-II. | ||
When FAS-II <scene name='Sandbox/Ache_1fss/7'>binds</scene> to AChE, Arg27 and Met33 interact with trp279 of the Peripheral Anionic Site, while Val34 and Thr8 interact with tyr70 of the Peripheral Anionic Site. Once this interaction occurs, the entrance of the gorge is <scene name='Sandbox_250/Ache_fas2/1'>covered</scene> such that acetylcholine may not enter. | When FAS-II <scene name='Sandbox/Ache_1fss/7'>binds</scene> to AChE, Arg27 and Met33 interact with trp279 of the Peripheral Anionic Site, while Val34 and Thr8 interact with tyr70 of the Peripheral Anionic Site. Once this interaction occurs, the entrance of the gorge is <scene name='Sandbox_250/Ache_fas2/1'>covered</scene> such that acetylcholine may not enter. | ||