3pgh: Difference between revisions

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[[Image:3pgh.gif|left|200px]]<br /><applet load="3pgh" size="450" color="white" frame="true" align="right" spinBox="true"  
[[Image:3pgh.gif|left|200px]]<br /><applet load="3pgh" size="350" color="white" frame="true" align="right" spinBox="true"  
caption="3pgh, resolution 2.5&Aring;" />
caption="3pgh, resolution 2.5&Aring;" />
'''CYCLOOXYGENASE-2 (PROSTAGLANDIN SYNTHASE-2) COMPLEXED WITH A NON-SELECTIVE INHIBITOR, FLURBIPROFEN'''<br />
'''CYCLOOXYGENASE-2 (PROSTAGLANDIN SYNTHASE-2) COMPLEXED WITH A NON-SELECTIVE INHIBITOR, FLURBIPROFEN'''<br />
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==About this Structure==
==About this Structure==
3PGH is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus] with NAG, HEM and FLP as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Prostaglandin-endoperoxide_synthase Prostaglandin-endoperoxide synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.99.1 1.14.99.1] Known structural/functional Sites: <scene name='pdbsite=ACE:SER 530 Is Acetylated By Aspirin (An Acetyl Group Is Cov ...'>ACE</scene>, <scene name='pdbsite=CAT:TYR 385 Is Believed To Be The Amino Acid That Abstracts ...'>CAT</scene>, <scene name='pdbsite=HEM:HIS 388 Is The Axial Ligand To The Heme'>HEM</scene> and <scene name='pdbsite=SUB:ARG 120 Is Believed To Anchor The Carboxylate Of Substra ...'>SUB</scene>. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=3PGH OCA].  
3PGH is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus] with <scene name='pdbligand=NAG:'>NAG</scene>, <scene name='pdbligand=HEM:'>HEM</scene> and <scene name='pdbligand=FLP:'>FLP</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Prostaglandin-endoperoxide_synthase Prostaglandin-endoperoxide synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.99.1 1.14.99.1] Known structural/functional Sites: <scene name='pdbsite=ACE:SER+530+Is+Acetylated+By+Aspirin+(An+Acetyl+Group+Is+Cov+...'>ACE</scene>, <scene name='pdbsite=CAT:TYR+385+Is+Believed+To+Be+The+Amino+Acid+That+Abstracts+...'>CAT</scene>, <scene name='pdbsite=HEM:HIS+388+Is+The+Axial+Ligand+To+The+Heme'>HEM</scene> and <scene name='pdbsite=SUB:ARG+120+Is+Believed+To+Anchor+The+Carboxylate+Of+Substra+...'>SUB</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PGH OCA].  


==Reference==
==Reference==
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[[Category: prostaglandin synthase]]
[[Category: prostaglandin synthase]]


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