3iq7: Difference between revisions

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[[Image:3iq7.png|left|200px]]
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{{STRUCTURE_3iq7|  PDB=3iq7  |  SCENE=  }}  
{{STRUCTURE_3iq7|  PDB=3iq7  |  SCENE=  }}  
===Crystal Structure of human Haspin in complex with 5-Iodotubercidin===
===Crystal Structure of human Haspin in complex with 5-Iodotubercidin===
{{ABSTRACT_PUBMED_19918057}}


 
==Function==
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[[http://www.uniprot.org/uniprot/HASP_HUMAN HASP_HUMAN]] Serine/threonine-protein kinase that phosphorylates histone H3 at 'Ser-3' (H3T3ph) during mitosis. This positions and activates AURKB and other components of the chromosomal passenger complex (CPC) at centromeres to ensure proper chromatid cohesion, metaphase alignment and normal progression through the cell cycle.<ref>PMID:11228240</ref><ref>PMID:15681610</ref><ref>PMID:17084365</ref><ref>PMID:20705812</ref><ref>PMID:20929775</ref>  
The line below this paragraph, {{ABSTRACT_PUBMED_19918057}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 19918057 is the PubMed ID number.
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{{ABSTRACT_PUBMED_19918057}}


==About this Structure==
==About this Structure==
3IQ7 is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IQ7 OCA].  
[[3iq7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IQ7 OCA].  


==Reference==
==Reference==
<ref group="xtra">PMID:19918057</ref><references group="xtra"/>
<ref group="xtra">PMID:019918057</ref><references group="xtra"/><references/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Non-specific serine/threonine protein kinase]]
[[Category: Non-specific serine/threonine protein kinase]]
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[[Category: Structural genomics consortium]]
[[Category: Structural genomics consortium]]
[[Category: Transferase]]
[[Category: Transferase]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Sep  1 09:22:49 2010''

Revision as of 12:23, 27 March 2013

Template:STRUCTURE 3iq7

Crystal Structure of human Haspin in complex with 5-IodotubercidinCrystal Structure of human Haspin in complex with 5-Iodotubercidin

Template:ABSTRACT PUBMED 19918057

FunctionFunction

[HASP_HUMAN] Serine/threonine-protein kinase that phosphorylates histone H3 at 'Ser-3' (H3T3ph) during mitosis. This positions and activates AURKB and other components of the chromosomal passenger complex (CPC) at centromeres to ensure proper chromatid cohesion, metaphase alignment and normal progression through the cell cycle.[1][2][3][4][5]

About this StructureAbout this Structure

3iq7 is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

ReferenceReference

[xtra 1]

  1. ↑ Eswaran J, Patnaik D, Filippakopoulos P, Wang F, Stein RL, Murray JW, Higgins JM, Knapp S. Structure and functional characterization of the atypical human kinase haspin. Proc Natl Acad Sci U S A. 2009 Dec 1;106(48):20198-203. Epub 2009 Nov 16. PMID:19918057 doi:10.1073/pnas.0901989106
  1. ↑ Tanaka H, Iguchi N, Nakamura Y, Kohroki J, de Carvalho CE, Nishimune Y. Cloning and characterization of human haspin gene encoding haploid germ cell-specific nuclear protein kinase. Mol Hum Reprod. 2001 Mar;7(3):211-8. PMID:11228240
  2. ↑ Dai J, Sultan S, Taylor SS, Higgins JM. The kinase haspin is required for mitotic histone H3 Thr 3 phosphorylation and normal metaphase chromosome alignment. Genes Dev. 2005 Feb 15;19(4):472-88. Epub 2005 Jan 28. PMID:15681610 doi:gad.1267105
  3. ↑ Dai J, Sullivan BA, Higgins JM. Regulation of mitotic chromosome cohesion by Haspin and Aurora B. Dev Cell. 2006 Nov;11(5):741-50. PMID:17084365 doi:10.1016/j.devcel.2006.09.018
  4. ↑ Wang F, Dai J, Daum JR, Niedzialkowska E, Banerjee B, Stukenberg PT, Gorbsky GJ, Higgins JM. Histone H3 Thr-3 phosphorylation by Haspin positions Aurora B at centromeres in mitosis. Science. 2010 Oct 8;330(6001):231-5. doi: 10.1126/science.1189435. Epub 2010 Aug , 12. PMID:20705812 doi:10.1126/science.1189435
  5. ↑ Yamagishi Y, Honda T, Tanno Y, Watanabe Y. Two histone marks establish the inner centromere and chromosome bi-orientation. Science. 2010 Oct 8;330(6001):239-43. doi: 10.1126/science.1194498. PMID:20929775 doi:10.1126/science.1194498

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