Peroxisome Proliferator-Activated Receptors: Difference between revisions

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David Canner, Alexander Berchansky, Michal Harel, Joel L. Sussman

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 ===DNA Binding Domain Structure===
 [[Image:Rosiglitazone.png|300px|left|thumb| Human PPARγ agonist, Rosiglitazone (Avandia)]]
-PPARs also contain a DNA binding domain (DBD) The <scene name='Peroxisome_Proliferator-Activated_Receptors/Zinc_fingers/1'>DBD consist of two zinc fingers</scene>, one on PPAR and one on RXR, that bind PPREs of PPAR-responsive genes. The consensus sequence of PPREs is AGGTCA and has been found in a number of PPAR inducible genes like acyl-CoA oxidase and adipocyte fatty acid-binding protein.<ref>PMID:9383428</ref> It is believed that the DNA PPRE actually allosterically contributes to its own binding by directing a head-to-tail interaction between the PPAR DBD and RXR DBD via residues Gln206 and Arg209 on RXRα and Asn160 on PPARγ.<ref>PMID:19043829</ref>
+PPARs also contain a DNA binding domain (DBD) The <scene name='Peroxisome_Proliferator-Activated_Receptors/Zinc_fingers/1'>DBD consist of two zinc fingers</scene>, one on PPAR and one on RXR, that bind PPREs of PPAR-responsive genes. The consensus sequence of PPREs is AGGTCA and has been found in a number of PPAR inducible genes like acyl-CoA oxidase and adipocyte fatty acid-binding protein.<ref>PMID:9383428</ref> It is believed that the DNA PPRE actually allosterically contributes to its own binding by via a <scene name='Peroxisome_Proliferator-Activated_Receptors/Dbd_hbonds/1'>head-to-tail interaction between the PPAR DBD and RXR DBD</scene> using residues Gln206 and Arg209 on RXRα and Asn160 on PPARγ.<ref>PMID:19043829</ref>
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 ==Binding of Synthetic Agonists and Medical Implications==