Peroxisome Proliferator-Activated Receptors: Difference between revisions
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==Natural Ligands== | ==Natural Ligands== | ||
[[Image: Linoleic_Acid.png|400px|left|thumb| PPARγ Ligand, Linoleic Acid]] | [[Image: Linoleic_Acid.png|400px|left|thumb| PPARγ Ligand, Linoleic Acid]] | ||
<applet load=" 1i7g2.pdb" size="400" color="white" frame="true" spin="on" Scene ="Peroxisome_Proliferator-Activated_Receptors/Ppar_opening_2/2" caption="Crystal Structure of Human <scene name='Peroxisome_Proliferator-Activated_Receptors/Ppar_opening_2/2'> | <applet load=" 1i7g2.pdb" size="400" color="white" frame="true" spin="on" Scene ="Peroxisome_Proliferator-Activated_Receptors/Ppar_opening_2/2" caption="Crystal Structure of Human PAPR" align="right"/> | ||
<scene name='Peroxisome_Proliferator-Activated_Receptors/Ppar_opening_2/2'>PPARγ</scene> binds polyunsaturated fatty acids like linoleic acid, linolenic acid, and [http://en.wikipedia.org/wiki/Eicosapentaenoic_acid eicosapentaenoic acid] at affinities that are in line with serum levels. PPARα binds a variety of saturated and unsaturated fatty acids including [http://en.wikipedia.org/wiki/Palmitic_acid palmitic acid], [http://en.wikipedia.org/wiki/Oleic_acid oleic acid], [http://en.wikipedia.org/wiki/Linoleic_acid linoleic acid], and arachidonic acid.<ref>PMID:1316614</ref> PPARδs ligand selectivity is intermediate between that of the other isotypes and is activated by palmitic acid and a number of eicosanoids.<ref>PMID:7836471</ref> | |||
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