Severin: Difference between revisions
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{{STRUCTURE_3fg6| PDB=3fg6 | SCENE=Severin/Cv/1 |CAPTION=Severin, [[3fg6]] }} | {{STRUCTURE_3fg6| PDB=3fg6 | SCENE=Severin/Cv/1 |CAPTION=Severin, [[3fg6]] }} | ||
[[ | [[Severin]] is a calcium-activated protein which binds actin. The images at the top and at the right correspond to one representative Severin structure, ''i.e.'' human Severin ([[3fg6]]). It nucleates actin assembly, severes F-actin and caps actin filaments. Severin is a member of the calcium-regulated gelsolin superfamily of actin severing and capping proteins. Severin comprises 6 homologous domains (A1-A6), which share 60% identity with the 6 domains from [[Gelsolin]] (G1-G6). It is named Adseverin and Scinderin as well. The image at the right is an <scene name='Severin/Cv/2'>octamer</scene> (each monomer is colored in different color) of the Severin with <scene name='Severin/Cv/3'>calcium ions</scene> (<font color='lime'><b>colored lime</b></font>). | ||
== 3D Structures of Severin == | == 3D Structures of Severin == | ||
Revision as of 08:52, 2 August 2010
Severin is a calcium-activated protein which binds actin. The images at the top and at the right correspond to one representative Severin structure, i.e. human Severin (3fg6). It nucleates actin assembly, severes F-actin and caps actin filaments. Severin is a member of the calcium-regulated gelsolin superfamily of actin severing and capping proteins. Severin comprises 6 homologous domains (A1-A6), which share 60% identity with the 6 domains from Gelsolin (G1-G6). It is named Adseverin and Scinderin as well. The image at the right is an (each monomer is colored in different color) of the Severin with (colored lime).
3D Structures of Severin3D Structures of Severin
3fg6 – Adseverin C-terminal – human
1svy – Severin domain 2 – Dictyostelium discoideum
1svq - Severin domain 2 - Dictyostelium discoideum, NMR