2cm0: Difference between revisions
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[[Image:2cm0.gif|left|200px]]<br /><applet load="2cm0" size=" | [[Image:2cm0.gif|left|200px]]<br /><applet load="2cm0" size="350" color="white" frame="true" align="right" spinBox="true" | ||
caption="2cm0, resolution 1.9Å" /> | caption="2cm0, resolution 1.9Å" /> | ||
'''THE PUB DOMAIN FUNCTIONS AS A P97 BINDING MODULE IN HUMAN PEPTIDE N-GLYCANASE.'''<br /> | '''THE PUB DOMAIN FUNCTIONS AS A P97 BINDING MODULE IN HUMAN PEPTIDE N-GLYCANASE.'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
2CM0 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with BME and PEG as [http://en.wikipedia.org/wiki/ligands ligands]. Known structural/functional Site: <scene name='pdbsite=AC1:Bme Binding Site For Chain A'>AC1</scene>. Full crystallographic information is available from [http:// | 2CM0 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=BME:'>BME</scene> and <scene name='pdbligand=PEG:'>PEG</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Known structural/functional Site: <scene name='pdbsite=AC1:Bme+Binding+Site+For+Chain+A'>AC1</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CM0 OCA]. | ||
==Reference== | ==Reference== | ||
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[[Category: transferase]] | [[Category: transferase]] | ||
''Page seeded by [http:// | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Feb 3 10:36:46 2008'' | ||
Revision as of 11:36, 3 February 2008
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THE PUB DOMAIN FUNCTIONS AS A P97 BINDING MODULE IN HUMAN PEPTIDE N-GLYCANASE.
OverviewOverview
The AAA ATPase p97 is a ubiquitin-selective molecular machine involved in, multiple cellular processes, including protein degradation through the, ubiquitin-proteasome system and homotypic membrane fusion. Specific p97, functions are mediated by a variety of cofactors, among them peptide, N-glycanase, an enzyme that removes glycans from misfolded glycoproteins., Here we report the three-dimensional structure of the aminoterminal PUB, domain of human peptide N-glycanase. We demonstrate that the PUB domain is, a novel p97 binding module interacting with the D1 and/or D2 ATPase, domains of p97 and identify an evolutionary conserved surface patch, required for p97 binding. Furthermore, we show that the PUB and UBX, domains do not bind to p97 in a mutually exclusive manner. Our results, suggest that PUB domain-containing proteins constitute a widespread family, of diverse p97 cofactors.
About this StructureAbout this Structure
2CM0 is a Single protein structure of sequence from Homo sapiens with and as ligands. Known structural/functional Site: . Full crystallographic information is available from OCA.
ReferenceReference
The PUB domain functions as a p97 binding module in human peptide N-glycanase., Allen MD, Buchberger A, Bycroft M, J Biol Chem. 2006 Sep 1;281(35):25502-8. Epub 2006 Jun 28. PMID:16807242
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