3n00: Difference between revisions
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{{STRUCTURE_3n00| PDB=3n00 | SCENE= }} | {{STRUCTURE_3n00| PDB=3n00 | SCENE= }} | ||
===Crystal Structure of a deletion mutant of human Reverba ligand binding domain bound with an NCoR ID1 peptide determined to 2.60A=== | ===Crystal Structure of a deletion mutant of human Reverba ligand binding domain bound with an NCoR ID1 peptide determined to 2.60A=== | ||
{{ABSTRACT_PUBMED_20581824}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/NR1D1_HUMAN NR1D1_HUMAN]] Functions as a constitutive transcriptional repressor. In collaboration with SP1, activates GJA1 transcription (By similarity). Possible receptor for triiodothyronine.<ref>PMID:2539258</ref> <ref>PMID:1971514</ref> [[http://www.uniprot.org/uniprot/NCOR1_HUMAN NCOR1_HUMAN]] Mediates transcriptional repression by certain nuclear receptors. Part of a complex which promotes histone deacetylation and the formation of repressive chromatin structures which may impede the access of basal transcription factors.<ref>PMID:14527417</ref> | |||
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==About this Structure== | ==About this Structure== | ||
[[3n00]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3N00 OCA]. | |||
==Reference== | ==Reference== | ||
<ref group="xtra">PMID: | <ref group="xtra">PMID:020581824</ref><references group="xtra"/><references/> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Gampe, R.]] | [[Category: Gampe, R.]] | ||
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[[Category: Reverba ncorid1]] | [[Category: Reverba ncorid1]] | ||
[[Category: Transcription regulator]] | [[Category: Transcription regulator]] | ||