3mj5: Difference between revisions

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-{{Seed}}
-[[Image:3mj5.png|left|200px]]
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 {{STRUCTURE_3mj5|  PDB=3mj5  |  SCENE=  }}
 ===Severe Acute Respiratory Syndrome-Coronavirus Papain-Like Protease Inhibitors: Design, Synthesis, Protein-Ligand X-ray Structure and Biological Evaluation===
+{{ABSTRACT_PUBMED_20527968}}
+==Function==
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+[[http://www.uniprot.org/uniprot/R1A_CVHSA R1A_CVHSA]] The papain-like proteinase (PL-PRO) is responsible for the cleavages located at the N-terminus of replicase polyprotein. In addition, PL-PRO possesses a deubiquitinating/deISGylating activity and processes both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains from cellular substrates. Antagonizes innate immune induction of type I interferon by blocking the phosphorylation, dimerization and subsequent nuclear translocation of host IRF-3.<ref>PMID:17024178</ref> <ref>PMID:17692280</ref> <ref>PMID:19369340</ref>   The main proteinase 3CL-PRO is responsible for the majority of cleavages as it cleaves the C-terminus of replicase polyprotein at 11 sites. Recognizes substrates containing the core sequence [ILMVF]-Q-|-[SGACN]. Inhibited by the substrate-analog Cbz-Val-Asn-Ser-Thr-Leu-Gln-CMK (By similarity). Also contains an ADP-ribose-1''-phosphate (ADRP)-binding function.<ref>PMID:17024178</ref> <ref>PMID:17692280</ref> <ref>PMID:19369340</ref>   Nsp7-nsp8 hexadecamer may possibly confer processivity to the polymerase, maybe by binding to dsRNA or by producing primers utilized by the latter.<ref>PMID:17024178</ref> <ref>PMID:17692280</ref> <ref>PMID:19369340</ref>   Nsp9 is a ssRNA-binding protein.<ref>PMID:17024178</ref> <ref>PMID:17692280</ref> <ref>PMID:19369340</ref>
-The line below this paragraph, {{ABSTRACT_PUBMED_20527968}}, adds the Publication Abstract to the page
-(as it appears on PubMed at http://www.pubmed.gov), where 20527968 is the PubMed ID number.
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-{{ABSTRACT_PUBMED_20527968}}
 ==About this Structure==
-MJ5 is a 2 chains structure with sequences from [http://en.wikipedia.org/wiki/Sars_coronavirus Sars coronavirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MJ5 OCA].
+[[3mj5]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Sars_coronavirus Sars coronavirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MJ5 OCA].
 ==Reference==
-<ref group="xtra">PMID:20527968</ref><references group="xtra"/>
+<ref group="xtra">PMID:020527968</ref><references group="xtra"/><references/>
 [[Category: Sars coronavirus]]
 [[Category: Mesecar, A D.]]
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 [[Category: Viral protein]]
 [[Category: Zinc-finger]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 14 15:55:45 2010''