Urea transporter: Difference between revisions
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{{STRUCTURE_3k3f| PDB=3k3f | SCENE= }} | {{STRUCTURE_3k3f| PDB=3k3f | SCENE= }} | ||
{{Structure | |||
|PDB= 3k3f |SIZE=400|SCENE= |CAPTION= urea transporter (3k3f), resolution 2.30Å (<scene name='User:Wayne_Decatur/Sandbox_Glutamate_receptor/Default3kg2/1'>initial scene</scene>) | |||
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3k3f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3k3f OCA], [http://www.ebi.ac.uk/pdbsum/3k3f PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=3k3f RCSB]</span> | |||
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===Crystal Structure of the Urea Transporter from Desulfovibrio Vulgaris=== | ===Crystal Structure of the Urea Transporter from Desulfovibrio Vulgaris=== | ||
Revision as of 05:11, 4 July 2010
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| urea transporter (3k3f), resolution 2.30Å () | |||||||
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| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Crystal Structure of the Urea Transporter from Desulfovibrio VulgarisCrystal Structure of the Urea Transporter from Desulfovibrio Vulgaris
Urea is highly concentrated in the mammalian kidney to produce the osmotic gradient necessary for water re-absorption. Free diffusion of urea across cell membranes is slow owing to its high polarity, and specialized urea transporters have evolved to achieve rapid and selective urea permeation. Here we present the 2.3 A structure of a functional urea transporter from the bacterium Desulfovibrio vulgaris. The transporter is a homotrimer, and each subunit contains a continuous membrane-spanning pore formed by the two homologous halves of the protein. The pore contains a constricted selectivity filter that can accommodate several dehydrated urea molecules in single file. Backbone and side-chain oxygen atoms provide continuous coordination of urea as it progresses through the filter, and well-placed alpha-helix dipoles provide further compensation for dehydration energy. These results establish that the urea transporter operates by a channel-like mechanism and reveal the physical and chemical basis of urea selectivity.
Crystal structure of a bacterial homologue of the kidney urea transporter., Levin EJ, Quick M, Zhou M, Nature. 2009 Dec 10;462(7274):757-61. Epub . PMID:19865084
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
About this StructureAbout this Structure
3K3F is a 1 chain structure with sequence from Desulfovibrio vulgaris str. hildenborough. Full crystallographic information is available from OCA.
ReferenceReference
- ↑ Levin EJ, Quick M, Zhou M. Crystal structure of a bacterial homologue of the kidney urea transporter. Nature. 2009 Dec 10;462(7274):757-61. Epub . PMID:19865084 doi:10.1038/nature08558
Page started with original page on 3k3f seeded by OCA on Thu Jan 28 14:58:46 2010