User:Janice C. Telfer/Group B SRCR domains: Difference between revisions

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<scene name='Sandbox_Reserved_101/Cd5iii/5'>HsCD5 group B SRCR domain 3 disulfide bonds</scene>

Group B SRCR domains bind to both protein and non-petidic ligands. In the latter class of ligands are molecules found on bacteria, such as lipopolysaccharide (LPS) and lipoteichoic acid (LTA), which suggests that group B SRCR proteins play a role in the host immune response to microorganisms. The group B SRCR domain family member WC1 appears to play an important role in the bovine response to the spirochaete Leptospira as a co-receptor whose tyrosine phosphorylation is required for optimal gamma delta T cell response. There are approximately 15 different WC1 genes in the bovine genome

Group B SRCR domains bind to both protein and non-petidic ligands. In the latter class of ligands are molecules found on bacteria, such as lipopolysaccharide (LPS) and lipoteichoic acid (LTA), which suggests that group B SRCR proteins play a role in the host immune response to microorganisms. The group B SRCR domain family member WC1 appears to play an important role in the bovine response to the spirochaete Leptospira as a co-receptor whose tyrosine phosphorylation is required for optimal gamma delta T cell response (Wang, F. et al 2009 Eur. J. Immunol. 39:254-66). There are approximately 15 different WC1 genes in the bovine genome (Herzig,C.T. and C.L. Baldwin 2009 BMC Genomics 10:191), but only a subset of them participate in the immune response to Leptospira (Rogers,A.N. et al 2005 J. Immunol. 174:3386-93). This subset is labelled by an antibody recognizing the first WC1 cloned, known as WC1.1. A subset labelled by an antibody recognizing the second WC1 cloned, known as WC1.2, does not participate in the immune response to Leptospira. Anti-WC1-1 recognizes SRCR domain 1 of WC1-1, WC1-3, WC1-11 and WC1-nd1; anti-WC1.2 recognizes SRCR domain 1 of WC1-4 and WC1-9 (Chen, C. et al 2009 Molecular Immunology 46:2565-75).

<scene name='Sandbox_Reserved_101/Wc1-1a/3'>WC1-1 SRCR domain 1a (WC1.1+)</scene>

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 <scene name='Sandbox_Reserved_101/Cd5iii/5'>HsCD5 group B SRCR domain 3 disulfide bonds</scene>
-Group B SRCR domains bind to both protein and non-petidic ligands. In the latter class of ligands are molecules found on bacteria, such as lipopolysaccharide (LPS) and lipoteichoic acid (LTA), which suggests that group B SRCR proteins play a role in the host immune response to microorganisms. The group B SRCR domain family member WC1 appears to play an important role in the bovine response to the spirochaete Leptospira as a co-receptor whose tyrosine phosphorylation is required for optimal gamma delta T cell response.  There are approximately 15 different WC1 genes in the bovine genome
+Group B SRCR domains bind to both protein and non-petidic ligands. In the latter class of ligands are molecules found on bacteria, such as lipopolysaccharide (LPS) and lipoteichoic acid (LTA), which suggests that group B SRCR proteins play a role in the host immune response to microorganisms. The group B SRCR domain family member WC1 appears to play an important role in the bovine response to the spirochaete Leptospira as a co-receptor whose tyrosine phosphorylation is required for optimal gamma delta T cell response (Wang, F. et al 2009 Eur. J. Immunol. 39:254-66).  There are approximately 15 different WC1 genes in the bovine genome (Herzig,C.T. and C.L. Baldwin 2009 BMC Genomics 10:191), but only a subset of them participate in the immune response to Leptospira (Rogers,A.N. et al 2005 J. Immunol. 174:3386-93). This subset is labelled by an antibody recognizing the first WC1 cloned, known as WC1.1. A subset labelled by an antibody recognizing the second WC1 cloned, known as WC1.2, does not participate in the immune response to Leptospira. Anti-WC1-1 recognizes SRCR domain 1 of WC1-1, WC1-3, WC1-11 and WC1-nd1; anti-WC1.2 recognizes SRCR domain 1 of WC1-4 and WC1-9 (Chen, C. et al 2009 Molecular Immunology 46:2565-75).
 <scene name='Sandbox_Reserved_101/Wc1-1a/3'>WC1-1 SRCR domain 1a (WC1.1+)</scene>