2bgl: Difference between revisions
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Revision as of 17:32, 30 October 2007
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X-RAY STRUCTURE OF BINARY-SECOISOLARICIRESINOL DEHYDROGENASE
OverviewOverview
(-)-Matairesinol is a central biosynthetic intermediate to numerous, 8-8'-lignans, including the antiviral agent podophyllotoxin in Podophyllum, species and its semi-synthetic anticancer derivatives teniposide, etoposide, and Etopophos. It is formed by action of an enantiospecific, secoisolariciresinol dehydrogenase, an NAD(H)-dependent oxidoreductase, that catalyzes the conversion of (-)-secoisolariciresinol. Matairesinol is, also a plant-derived precursor of the cancer-preventative "mammalian", lignan or "phytoestrogen" enterolactone, formed in the gut following, ingestion of high fiber dietary foodstuffs, for example. Additionally, secoisolariciresinol dehydrogenase is involved in pathways to important, plant defense molecules, such as plicatic acid in the western red cedar, (Thuja ... [(full description)]
About this StructureAbout this Structure
2BGL is a [Single protein] structure of sequence from [Podophyllum peltatum] with NAJ as [ligand]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].
ReferenceReference
Crystal structures of apo-form and binary/ternary complexes of Podophyllum secoisolariciresinol dehydrogenase, an enzyme involved in formation of health-protecting and plant defense lignans., Youn B, Moinuddin SG, Davin LB, Lewis NG, Kang C, J Biol Chem. 2005 Apr 1;280(13):12917-26. Epub 2005 Jan 13. PMID:15653677
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