3me2: Difference between revisions

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{{Seed}}
[[Image:3me2.jpg|left|200px]]
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{{STRUCTURE_3me2|  PDB=3me2  |  SCENE=  }}  
{{STRUCTURE_3me2|  PDB=3me2  |  SCENE=  }}  
===Crystal structure of mouse RANKL-RANK complex===
===Crystal structure of mouse RANKL-RANK complex===
{{ABSTRACT_PUBMED_20483727}}


==Disease==
[[http://www.uniprot.org/uniprot/TNF11_MOUSE TNF11_MOUSE]] Note=Deficiency in Tnfsf11 results in failure to form lobulo-alveolar mammary structures during pregnancy, resulting in death of newborns. Trance-deficient mice show severe osteopetrosis, with no osteoclasts, marrow spaces, or tooth eruption, and exhibit profound growth retardation at several skeletal sites, including the limbs, skull, and vertebrae and have marked chondrodysplasia, with thick, irregular growth plates and a relative increase in hypertrophic chondrocytes.


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==Function==
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[[http://www.uniprot.org/uniprot/TNF11_MOUSE TNF11_MOUSE]] Cytokine that binds to TNFRSF11B/OPG and to TNFRSF11A/RANK. Osteoclast differentiation and activation factor. Augments the ability of dendritic cells to stimulate naive T-cell proliferation. May be an important regulator of interactions between T-cells and dendritic cells and may play a role in the regulation of the T-cell-dependent immune response. May also play an important role in enhanced bone-resorption in humoral hypercalcemia of malignancy. [[http://www.uniprot.org/uniprot/TNR11_MOUSE TNR11_MOUSE]] Receptor for TNFSF11/RANKL/TRANCE/OPGL; essential for RANKL-mediated osteoclastogenesis. Involved in the regulation of interactions between T-cells and dendritic cells.<ref>PMID:9878548</ref><ref>PMID:20483727</ref>  
(as it appears on PubMed at http://www.pubmed.gov), where 20483727 is the PubMed ID number.
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{{ABSTRACT_PUBMED_20483727}}


==About this Structure==
==About this Structure==
3ME2 is a 2 chains structure with sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ME2 OCA].  
[[3me2]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ME2 OCA].  


==Reference==
==Reference==
<ref group="xtra">PMID:20483727</ref><references group="xtra"/>
<ref group="xtra">PMID:020483727</ref><references group="xtra"/><references/>
[[Category: Mus musculus]]
[[Category: Mus musculus]]
[[Category: Gao, B.]]
[[Category: Gao, B.]]
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[[Category: Tnfrsf11a]]
[[Category: Tnfrsf11a]]
[[Category: Tnfsf11]]
[[Category: Tnfsf11]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jun  2 08:35:46 2010''

Revision as of 20:27, 24 March 2013

Template:STRUCTURE 3me2

Crystal structure of mouse RANKL-RANK complexCrystal structure of mouse RANKL-RANK complex

Template:ABSTRACT PUBMED 20483727

DiseaseDisease

[TNF11_MOUSE] Note=Deficiency in Tnfsf11 results in failure to form lobulo-alveolar mammary structures during pregnancy, resulting in death of newborns. Trance-deficient mice show severe osteopetrosis, with no osteoclasts, marrow spaces, or tooth eruption, and exhibit profound growth retardation at several skeletal sites, including the limbs, skull, and vertebrae and have marked chondrodysplasia, with thick, irregular growth plates and a relative increase in hypertrophic chondrocytes.

FunctionFunction

[TNF11_MOUSE] Cytokine that binds to TNFRSF11B/OPG and to TNFRSF11A/RANK. Osteoclast differentiation and activation factor. Augments the ability of dendritic cells to stimulate naive T-cell proliferation. May be an important regulator of interactions between T-cells and dendritic cells and may play a role in the regulation of the T-cell-dependent immune response. May also play an important role in enhanced bone-resorption in humoral hypercalcemia of malignancy. [TNR11_MOUSE] Receptor for TNFSF11/RANKL/TRANCE/OPGL; essential for RANKL-mediated osteoclastogenesis. Involved in the regulation of interactions between T-cells and dendritic cells.[1][2]

About this StructureAbout this Structure

3me2 is a 2 chain structure with sequence from Mus musculus. Full crystallographic information is available from OCA.

ReferenceReference

[xtra 1]

  1. ↑ Liu C, Walter TS, Huang P, Zhang S, Zhu X, Wu Y, Wedderburn LR, Tang P, Owens RJ, Stuart DI, Ren J, Gao B. Structural and functional insights of RANKL-RANK interaction and signaling. J Immunol. 2010 Jun 15;184(12):6910-9. Epub 2010 May 14. PMID:20483727 doi:10.4049/jimmunol.0904033
  1. ↑ Nakagawa N, Kinosaki M, Yamaguchi K, Shima N, Yasuda H, Yano K, Morinaga T, Higashio K. RANK is the essential signaling receptor for osteoclast differentiation factor in osteoclastogenesis. Biochem Biophys Res Commun. 1998 Dec 18;253(2):395-400. PMID:9878548 doi:S0006-291X(98)99788-1
  2. ↑ Liu C, Walter TS, Huang P, Zhang S, Zhu X, Wu Y, Wedderburn LR, Tang P, Owens RJ, Stuart DI, Ren J, Gao B. Structural and functional insights of RANKL-RANK interaction and signaling. J Immunol. 2010 Jun 15;184(12):6910-9. Epub 2010 May 14. PMID:20483727 doi:10.4049/jimmunol.0904033

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