3kdf: Difference between revisions
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{{STRUCTURE_3kdf| PDB=3kdf | SCENE= }} | {{STRUCTURE_3kdf| PDB=3kdf | SCENE= }} | ||
===X-ray Crystal Structure of the Human Replication Protein A Complex from Wheat Germ Cell Free Expression=== | ===X-ray Crystal Structure of the Human Replication Protein A Complex from Wheat Germ Cell Free Expression=== | ||
==Function== | |||
[[http://www.uniprot.org/uniprot/RFA3_HUMAN RFA3_HUMAN]] Required for DNA recombination, repair and replication. The activity of RP-A is mediated by single-stranded DNA binding and protein interactions.<ref>PMID:19116208</ref> <ref>PMID:19996105</ref> Functions as component of the alternative replication protein A complex (aRPA). aRPA binds single-stranded DNA and probably plays a role in DNA repair; it does not support chromosomal DNA replication and cell cycle progression through S-phase. In vitro, aRPA cannot promote efficient priming by DNA polymerase alpha but supports DNA polymerase delta synthesis in the presence of PCNA and replication factor C (RFC), the dual incision/excision reaction of nucleotide excision repair and RAD51-dependent strand exchange.<ref>PMID:19116208</ref> <ref>PMID:19996105</ref> [[http://www.uniprot.org/uniprot/RFA2_HUMAN RFA2_HUMAN]] Required for DNA recombination, repair and replication. The activity of RP-A is mediated by single-stranded DNA binding and protein interactions. Required for the efficient recruitment of the DNA double-strand break repair factor RAD51 to chromatin in response to DNA damage.<ref>PMID:15205463</ref> <ref>PMID:19116208</ref> <ref>PMID:19996105</ref> <ref>PMID:20154705</ref> Functions as component of the alternative replication protein A complex (aRPA). aRPA binds single-stranded DNA and probably plays a role in DNA repair; it does not support chromosomal DNA replication and cell cycle progression through S-phase. In vitro, aRPA cannot promote efficient priming by DNA polymerase alpha but supports DNA polymerase delta synthesis in the presence of PCNA and replication factor C (RFC), the dual incision/excision reaction of nucleotide excision repair and RAD51-dependent strand exchange.<ref>PMID:15205463</ref> <ref>PMID:19116208</ref> <ref>PMID:19996105</ref> <ref>PMID:20154705</ref> | |||
==About this Structure== | ==About this Structure== | ||
[[3kdf]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KDF OCA]. | |||
==Reference== | |||
<references group="xtra"/><references/> | |||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Bingman, C A.]] | [[Category: Bingman, C A.]] | ||
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[[Category: CESG, Center for Eukaryotic Structural Genomics.]] | [[Category: CESG, Center for Eukaryotic Structural Genomics.]] | ||
[[Category: Fox, B G.]] | [[Category: Fox, B G.]] | ||
[[Category: Makino, S I.]] | [[Category: Makino, S I.]] | ||
[[Category: | [[Category: Phillips, G N.]] | ||
[[Category: Center for eukaryotic structural genomic]] | [[Category: Center for eukaryotic structural genomic]] | ||
[[Category: Cesg]] | [[Category: Cesg]] | ||
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[[Category: Nucleus]] | [[Category: Nucleus]] | ||
[[Category: Phosphoprotein]] | [[Category: Phosphoprotein]] | ||
[[Category: Protein complex]] | [[Category: Protein complex]] | ||
[[Category: Protein structure initiative]] | [[Category: Protein structure initiative]] | ||
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[[Category: Replication protein some]] | [[Category: Replication protein some]] | ||
[[Category: Wheat germ cell free]] | [[Category: Wheat germ cell free]] | ||