3mcf: Difference between revisions
Jump to navigation
Jump to search
New page: {{Seed}} left|200px <!-- The line below this paragraph, containing "STRUCTURE_3mcf", creates the "Structure Box" on the page. You may change the PDB parameter (which se... |
No edit summary |
||
| Line 1: | Line 1: | ||
{{STRUCTURE_3mcf| PDB=3mcf | SCENE= }} | {{STRUCTURE_3mcf| PDB=3mcf | SCENE= }} | ||
===Crystal structure of human diphosphoinositol polyphosphate phosphohydrolase 3-alpha=== | ===Crystal structure of human diphosphoinositol polyphosphate phosphohydrolase 3-alpha=== | ||
==Function== | |||
[[http://www.uniprot.org/uniprot/NUD10_HUMAN NUD10_HUMAN]] Cleaves a beta-phosphate from the diphosphate groups in PP-InsP5 (diphosphoinositol pentakisphosphate), suggesting that it may play a role in signal transduction. Also able to catalyze the hydrolysis of dinucleoside oligophosphates, with Ap6A and Ap5A being the preferred substrates. The major reaction products are ADP and p4a from Ap6A and ADP and ATP from Ap5A. Also able to hydrolyze 5-phosphoribose 1-diphosphate. | |||
==About this Structure== | ==About this Structure== | ||
[[3mcf]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MCF OCA]. | |||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Arrowsmith, C H.]] | [[Category: Arrowsmith, C H.]] | ||
| Line 56: | Line 48: | ||
[[Category: Structural genomic]] | [[Category: Structural genomic]] | ||
[[Category: Structural genomics consortium]] | [[Category: Structural genomics consortium]] | ||
Revision as of 02:22, 11 April 2013
Crystal structure of human diphosphoinositol polyphosphate phosphohydrolase 3-alphaCrystal structure of human diphosphoinositol polyphosphate phosphohydrolase 3-alpha
FunctionFunction
[NUD10_HUMAN] Cleaves a beta-phosphate from the diphosphate groups in PP-InsP5 (diphosphoinositol pentakisphosphate), suggesting that it may play a role in signal transduction. Also able to catalyze the hydrolysis of dinucleoside oligophosphates, with Ap6A and Ap5A being the preferred substrates. The major reaction products are ADP and p4a from Ap6A and ADP and ATP from Ap5A. Also able to hydrolyze 5-phosphoribose 1-diphosphate.
About this StructureAbout this Structure
3mcf is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)
OCACategories:
- Homo sapiens
- Arrowsmith, C H.
- Berg, S van der.
- Berglund, H.
- Bountra, C.
- Collins, R.
- Edwards, A M.
- Flodin, S.
- Flores, A.
- Graslund, S.
- Hammarstrom, M.
- Johansson, I.
- Karlberg, T.
- Kol, S.
- Kotenyova, T.
- Moche, M.
- Nordlund, P.
- Nyman, T.
- Persson, C.
- SGC, Structural Genomics Consortium.
- Schuler, H.
- Schutz, P.
- Siponen, M I.
- Thorsell, A G.
- Tresaugues, L.
- Wahlberg, E.
- Weigelt, J.
- Welin, M.
- Wisniewska, M.
- Aps2
- Diphosphoinositol pentakisphosphate
- Dipp3a
- Hydrolase
- Metal-binding
- Nudix
- Nudt10
- Sgc
- Sgc stockholm
- Signal transduction
- Structural genomic
- Structural genomics consortium