Interleukin-10: Difference between revisions
No edit summary |
No edit summary |
||
| Line 1: | Line 1: | ||
== '''Interleukin-10''' '''[[2H24]]''' == | == '''Interleukin-10''' '''[[2H24]]''' == | ||
[[Image:2h24.png|right|thumb| Figure 1. IL-10 N-Terminus of helix A ]] | [[Image:2h24.png|right|thumb| Figure 1. IL-10 N-Terminus of helix A ]] | ||
Interleukin 10 is a ternary complex that requires specific assembly for proper function. The IL-10 complex is composed of IL-10,IL-10R1,IL-10R2. The initial step is the formation of IL-10 and IL-10R1 generating a conformational change that is required for IL-10R2 to be able to associate and form the ternary complex <ref name="ref1">PMID:16982608</ref>. The completed complex activates the [http://en.wikipedia.org/wiki/JAK-STAT_signaling_pathway JAK/STAT signaling pathway].[[Image:IL10.png|left|thumb|'''Figure 2. Sequential assembly of the ternary complex''' ]] The completion of the ternary complex is dependent on the conformational changes that occur in the N-Terminus of the helix labelled A. The conformational changes occur when the cIL-10 binds with IL-10R1. There is a positional change of about 1 angstrom at residues between Cys-12 and Leu-46. | Interleukin 10 is a ternary complex that requires specific assembly for proper function. The IL-10 complex is composed of IL-10,IL-10R1,IL-10R2. The initial step is the formation of IL-10 and IL-10R1 generating a conformational change that is required for IL-10R2 to be able to associate and form the ternary complex <ref name="ref1">PMID:16982608</ref>. The completed complex activates the [http://en.wikipedia.org/wiki/JAK-STAT_signaling_pathway JAK/STAT signaling pathway].[[Image:IL10.png|left|thumb|'''Figure 2. Sequential assembly of the ternary complex''' ]] The completion of the ternary complex is dependent on the conformational changes that occur in the N-Terminus of the helix labelled A. The conformational changes occur when the cIL-10 binds with IL-10R1. There is a positional change of about 1 angstrom at residues between Cys-12 and Leu-46. | ||
<scene name='Sandbox_165/2h24_backbone/1'>ball and stick of 2h24</scene> | <scene name='Sandbox_165/2h24_backbone/1'>ball and stick of 2h24</scene> | ||