Birrer Sandbox 2: Difference between revisions

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Revision as of 22:12, 31 March 2010 view source David Birrer (talk \| contribs) 81 edits No edit summary ← Older edit		Revision as of 22:49, 31 March 2010 view source David Birrer (talk \| contribs) 81 edits No edit summary Newer edit →
Line 24:		Line 24:


	The Mechanism for alcohol dehydrogenase follows an Ordered bisubstrate mechanism. The mechanism, then, is pretty straight forward: the NAD+ and alcohol bind to the enzyme, so that the enzyme is now attached to the two subtrates. While attached, the hydrogen is formally transferred from the alcohol to NAD, resulting in the products NADH and a ketone or aldehyde. The two products are then released, and the enzyme has catalyzed the reaction.		The Mechanism for alcohol dehydrogenase follows an Ordered bisubstrate mechanism.<ref>Voet, et. al. ''Fundamentals of Biochemistry: 3rd Edition''. Hoboken: Wiley & Sons, Inc, 2008.</ref> The mechanism, then, is pretty straight forward: the NAD+ and alcohol bind to the enzyme, so that the enzyme is now attached to the two subtrates. While attached, the hydrogen is formally transferred from the alcohol to NAD, resulting in the products NADH and a ketone or aldehyde. The two products are then released, and the enzyme has catalyzed the reaction.