1esf: Difference between revisions
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[[Image:1esf.gif|left|200px]]<br /><applet load="1esf" size=" | [[Image:1esf.gif|left|200px]]<br /><applet load="1esf" size="350" color="white" frame="true" align="right" spinBox="true" | ||
caption="1esf, resolution 1.9Å" /> | caption="1esf, resolution 1.9Å" /> | ||
'''STAPHYLOCOCCAL ENTEROTOXIN A'''<br /> | '''STAPHYLOCOCCAL ENTEROTOXIN A'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
1ESF is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus] with CD as [http://en.wikipedia.org/wiki/ligand ligand]. Known structural/functional Sites: <scene name='pdbsite=CD1:Cd 2+ Binding Site I'>CD1</scene> and <scene name='pdbsite=CD2:Cd 2+ Binding Site II'>CD2</scene>. Full crystallographic information is available from [http:// | 1ESF is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus] with <scene name='pdbligand=CD:'>CD</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Known structural/functional Sites: <scene name='pdbsite=CD1:Cd+2++Binding+Site+I'>CD1</scene> and <scene name='pdbsite=CD2:Cd+2++Binding+Site+II'>CD2</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ESF OCA]. | ||
==Reference== | ==Reference== | ||
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[[Category: staphylococcal enterotoxin type a]] | [[Category: staphylococcal enterotoxin type a]] | ||
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Revision as of 10:39, 3 February 2008
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STAPHYLOCOCCAL ENTEROTOXIN A
OverviewOverview
Staphylococcal enterotoxins are prototype superantigens characterized by, their ability to bind to major histocompatibility complex (MHC) class II, molecules and subsequently activate a large fraction of T-lymphocytes. The, crystal structure of staphylococcal enterotoxin type A (SEA), a 27 kDa, monomeric protein, was determined to 1.9 A resolution with an R-factor of, 19.9% by multiple isomorphous replacement. SEA is a two domain protein, composed of a beta-barrel and a beta-grasp motif demonstrating the same, general structure as staphylococcal enterotoxins SEB and TSST-1. Unique, for SEA, however, is a Zn2+ coordination site involved in MHC class II, binding. Four amino acids including Ser1, His187, His225 and Asp227 were, found to be involved in direct coordination of the metal ion. SEA is the, first Zn2+ binding enterotoxin that has been structurally determined.
About this StructureAbout this Structure
1ESF is a Single protein structure of sequence from Staphylococcus aureus with as ligand. Known structural/functional Sites: and . Full crystallographic information is available from OCA.
ReferenceReference
Crystal structure of the superantigen staphylococcal enterotoxin type A., Schad EM, Zaitseva I, Zaitsev VN, Dohlsten M, Kalland T, Schlievert PM, Ohlendorf DH, Svensson LA, EMBO J. 1995 Jul 17;14(14):3292-301. PMID:7628431
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