3lkx: Difference between revisions
No edit summary |
No edit summary |
||
Line 1: | Line 1: | ||
{{STRUCTURE_3lkx| PDB=3lkx | SCENE= }} | {{STRUCTURE_3lkx| PDB=3lkx | SCENE= }} | ||
===Human nac dimerization domain=== | ===Human nac dimerization domain=== | ||
{{ABSTRACT_PUBMED_20214399}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/BTF3_HUMAN BTF3_HUMAN]] General transcription factor. BTF3 can form a stable complex with RNA polymerase II. Required for the initiation of transcription. [[http://www.uniprot.org/uniprot/NACA_HUMAN NACA_HUMAN]] Prevents inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER). Binds to nascent polypeptide chains as they emerge from the ribosome and blocks their interaction with the signal recognition particle (SRP), which normally targets nascent secretory peptides to the ER. Also reduces the inherent affinity of ribosomes for protein translocation sites in the ER membrane (M sites). May act as a specific coactivator for JUN, binding to DNA and stabilizing the interaction of JUN homodimers with target gene promoters.<ref>PMID:9877153</ref> <ref>PMID:10982809</ref> <ref>PMID:15784678</ref> | |||
==About this Structure== | ==About this Structure== | ||
[[3lkx]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LKX OCA]. | |||
==Reference== | ==Reference== | ||
<ref group="xtra">PMID: | <ref group="xtra">PMID:020214399</ref><references group="xtra"/><references/> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Hu, Y.]] | [[Category: Hu, Y.]] | ||
Line 32: | Line 19: | ||
[[Category: Beta-barrel]] | [[Category: Beta-barrel]] | ||
[[Category: Chaperone]] | [[Category: Chaperone]] | ||