Inositol 1,4,5-Trisphosphate Receptor: Difference between revisions
Shannon King (talk | contribs) No edit summary |
Shannon King (talk | contribs) No edit summary |
||
| Line 60: | Line 60: | ||
The InsP<sub>3</sub>R protein can autophosphorylate itself and is a substrate for multiple protein kinases.<ref name="functionref"/> These kinases include cyclic AMP-dependent protein kinase (PKA), cyclic GMP-dependent protein kinase (PKG) and others.<ref name="functionref"/> The protein kinases are thought to interact with the InsP<sub>3</sub> receptor by controlling the sensitivity to Ca<sup>2+</sup> in different tissues as well as affecting the sensitivity of InsP<sub>3</sub> itself to Ca<sup>2+</sup>.<ref name="functionref"/> | The InsP<sub>3</sub>R protein can autophosphorylate itself and is a substrate for multiple protein kinases.<ref name="functionref"/> These kinases include cyclic AMP-dependent protein kinase (PKA), cyclic GMP-dependent protein kinase (PKG) and others.<ref name="functionref"/> The protein kinases are thought to interact with the InsP<sub>3</sub> receptor by controlling the sensitivity to Ca<sup>2+</sup> in different tissues as well as affecting the sensitivity of InsP<sub>3</sub> itself to Ca<sup>2+</sup>.<ref name="functionref"/> | ||