Anthony Noles Sandbox: Difference between revisions
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=Aconitase= | =Aconitase= | ||
Aconitase (PDB [[7acn]]) catalyzes the reversible isomerization of citrate and isocitrate. It is the second enzyme is the Citric acid cycle. The <scene name='Anthony_Noles_Sandbox/Secondary_structure/1'>secondary structure</scene> consists of numerous alternating alpha helices and beta sheets (SCOP classification α/β alternating). The tertiary structure is somewhat bilobed with the active site in the middle, and, since there is only one subunit, there is no quaternary structure. | Aconitase (PDB [[7acn]]) in a single polypeptide (M<sub>r</sub> 83kD) that catalyzes the reversible isomerization of citrate and isocitrate.<ref name="Zheng">Zheng, L., Kennedy, MC., Beinert, H., Zalkin, H. "Mutational analysis of ative site residues in pig heart aconitase." J Biol Chem 1992, 267, 7895-7903.</ref> It is the second enzyme is the Citric acid cycle. The <scene name='Anthony_Noles_Sandbox/Secondary_structure/1'>secondary structure</scene> consists of numerous alternating alpha helices and beta sheets (SCOP classification α/β alternating). The tertiary structure is somewhat bilobed with the active site in the middle, and, since there is only one subunit, there is no quaternary structure. | ||
==Mechanism of Aconitase== | ==Mechanism of Aconitase== | ||
{{STRUCTURE_7acn | PDB=7acn | SCENE= }} | {{STRUCTURE_7acn | PDB=7acn | SCENE= }} | ||