Interleukin-10: Difference between revisions
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IL-10 is investigated for its role in patients with [http://en.wikipedia.org/wiki/Rheumatoid_Arthritis Rheumatoid Arthritis] (RA) as well as those with [http://en.wikipedia.org/wiki/Osteoarthritis Osteoarthritis] (OA)<ref>PMID:8163935</ref>. | IL-10 is investigated for its role in patients with [http://en.wikipedia.org/wiki/Rheumatoid_Arthritis Rheumatoid Arthritis] (RA) as well as those with [http://en.wikipedia.org/wiki/Osteoarthritis Osteoarthritis] (OA)<ref>PMID:8163935</ref>. | ||
RA is an autoimmune disorder that affects the synovial tissues via chronic synovitis. Chronic synovitis often results in joint destruction due to re-absorption of bone and the distruction of cartilage<ref>PMID:19758192</ref> <ref>PMID:8163935</ref>. | RA is an autoimmune disorder that affects the synovial tissues via chronic synovitis. Chronic synovitis often results in joint destruction due to re-absorption of bone and the distruction of cartilage<ref>PMID:19758192</ref> <ref>PMID:8163935</ref>. | ||
IL-10 is found to spontaneously be produce in synovial tissue of patients with RA and OA but not in normal synovial tissue. | IL-10 is found to spontaneously be produce in synovial tissue of patients with RA and OA but not in normal synovial tissue.The variation in secretion of IL-10 is thought to be at about 75% under the control of the genetics of the individual<ref>PMID:19758192</ref>.When IL-10 is blocked there is a increase in the proinflammatory cytokines, namely TFN-α and Il-1β | ||
The variation in secretion of IL-10 is thought to be at about 75% under the control of the genetics of the individual<ref>PMID:19758192</ref>. | |||
When IL-10 is blocked there is a increase in the proinflammatory cytokines, namely TFN-α and Il-1β | |||
[[Image:Illu_synovial_joint.jpg]] | |||
>{{STRUCTURE_2h24| PDB=2h24| SCENE=Sandbox_165/Interleukin-10/1}} | >{{STRUCTURE_2h24| PDB=2h24| SCENE=Sandbox_165/Interleukin-10/1}} | ||