Jasper Lactate Final: Difference between revisions

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 ==Lactate Dehydrogenase==
-Lactate Dehydrogenase (LDH) is an important enzyme in humans. It occurs in different regions of the body, each region having a unique conformation of different subunits. The Jmole image shown is that of LDH-5, the form found in skeleton muscle and the liver.
+<scene name='Jasper_Small_Lactate_Sandbox_1/Basic/1'>Lactate Dehydrogenase (LDH)</scene> is an important enzyme in humans. It occurs in different regions of the body, each region having a unique conformation of different subunits. The Jmole image shown is that of LDH-5, the form found in skeleton muscle and the liver. LDH is a key enzyme in anaerobic respiration. Anaerobic Respiration is the conversion of pyruvate into lactate acid in the absence oxygen. This pathway is important to glycolysis in two main ways. The first is that if pyruvate were to build up glycoysis and thus the generation of ATP would slow. The second is anaerobic respiration allows for the regeneration of NAD+ from NADH. NAD+ is required when glyceraldehyde-3-phosphate dehydrogenase oxidizes glyceraldehyde-3-phosphate in glycolysis, which generates NADH. Lactate dehydrogenase is responsible for the anaerobic conversion of NADH to NAD+.
-==Function==
 [[Image:LDH_reaction.jpeg|left|thumb|355px|Catalytic function of LDH (1)]]
-LDH preforms an important metabolic function in the body. The enzyme catalyzes both the conversion of pyruvate to lactose as well as the conversion of lactose to pyruvate. The conversion of pyruvate to lactose occurs in the muscles of the body when oxygen is absent. The lactate acid is then moved back to the liver where LDH catalyzes the Cori cycle which converts the lactose back into pyruvate. The reaction is also important as it is coupled with the interconversion of NADH and NAD+.
+==Structure==
+LDH is a quaternary protein formed of the combination of two subunits, M and H (Muscle and Heart) into a structure of four of the subunits. The various combinations found in the human body are:
+*(4H) Heart
+*(3H1M) Reticuloendothelial
+*(2H2M) Lungs
+*(1H3M) Kidneys
+*(4M) Muscle and Liver
+The secondary structure of LDH is comprised of 40% alpha helices and 23% beta sheets.(2)
+SCOP
+I10- a/b Mainly parallel beta sheets (beta-alpha-beta units)
+I0Z- a/b Mainly parallel beta sheets (beta-alpha-beta units)
 ==Catalysis==
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 *<scene name='Jasper_Small_Lactate_Sandbox_1/Arg_171/1'>ARG 171</scene>
-==Structure==
-LDH is comprized of 40% alpha helixes and 23% beta sheets.(2)
-SCOP
-I10- a/b Mainly parallel beta sheets (beta-alpha-beta units)
-I0Z- a/b Mainly parallel beta sheets (beta-alpha-beta units)
-===Forms===
-LDH is a quaternary protein formed of the combination of two subunits, M and H (Muscle and Heart) into a structure of four of the subunits. The various combinations found in the human body are:
-*(4H) Heart
-*(3H1M) Reticuloendothelial
-*(2H2M) Lungs
-*(1H3M) Kidneys
-*(4M) Muscle and Liver