Michael nobbe sandbox 1: Difference between revisions
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Isocitrate dehydrogenase is SCOP classified as an alpha beta structure. Its secondary composition consists of mainly alpha helices and beta sheets which are arranged into three layer alpha beta alpha sandwich structures. The entire protein consists of two side by side sandwich structures that face opposite directions. This then causes the proteins two active sites to face opposite directions as well. These two groups make up the A and B subunits of isocitrate dehydrogenase. | Isocitrate dehydrogenase is SCOP classified as an alpha beta structure. Its secondary composition consists of mainly alpha helices and beta sheets which are arranged into three layer alpha beta alpha sandwich structures. The entire protein consists of two side by side sandwich structures that face opposite directions. This then causes the proteins two active sites to face opposite directions as well. These two groups make up the A and B subunits of isocitrate dehydrogenase. | ||
[[Image:Human isocitrate]] | [[Image:Human isocitrate.jpeg]] | ||
Human Isocitrate Dehydrogenase bound by NADH and CA2+ | Human Isocitrate Dehydrogenase bound by NADH and CA2+ | ||
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Image made using JMOL | Image made using JMOL | ||
[[Image:Chemicals isocitrate]] | [[Image:Chemicals isocitrate.jpeg]] | ||
Citric Acid is converted to alpha-ketoglutarate | Citric Acid is converted to alpha-ketoglutarate | ||