Glyceraldehyde-3-Phosphate Dehydrogenase: Difference between revisions

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 Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is a very important enzyme in the production of energy.  This enzyme catalyzes the sixth step in the process of breaking down glucose into energy, also known as glycolysis.  Though this is its main function, GAPDH has been shown to perform other functions including transcription activation, initiation of apoptosis, and ER to Golgi apparatus vesicle transportation.  However, this page will focus on GAPDH’s role in glysolysis.
-GAPDH most commonly exists as what looks to be a dimer.  Interesting though, the two monomers of the enzyme are not exactly the same.  While one side consists only of parallel beta-sheets, the other monomer is made up of both <scene name='Nathan_Line_sandbox_3/Secondary_structure/1'>beta-sheets and alpha helixes</scene>.  This is consistent with the following SCOP information:
+GAPDH most commonly exists as what looks to be a dimer.  Interesting though, the two monomers of the enzyme are not exactly the same.  While one side consists only of parallel and antiparallel beta-sheets, the other monomer is made up of both <scene name='Nathan_Line_sandbox_3/Secondary_structure/1'>beta-sheets and alpha helixes</scene>.  This is consistent with the following SCOP information:
 Class: Alpha and beta proteins (a/b)