Succinyl-CoA synthetase: Difference between revisions
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<applet load='1cqj' size='300' frame='true' align='right' caption='Structure of succinyl-CoA synthetase' /> | <applet load='1cqj' size='300' frame='true' align='right' caption='Structure of succinyl-CoA synthetase' /> | ||
'''Succinyl-Coa synthetase''' catalyzes the reversible reaction of succinyl-CoA + | '''Succinyl-Coa synthetase''' catalyzes the reversible reaction of succinyl-CoA + NDP + Pi <-> succinate + CoA + NTP (where N is either adenosine or guanosine. | ||
==Structure== | ==Structure== | ||
'''Succinyl-CoA synthetase''' is a tetramer with an active site on each dimer. This can be seen in the Jmol representation (the PDB code is 1CQJ). | '''Succinyl-CoA synthetase''' is a tetramer with an active site on each dimer. This can be seen in the Jmol representation (the PDB code is 1CQJ). The two dimers are denoted alpha and beta with a Histidine residue (His 246 alpha) being the primary catalysis through a phosphorylated histidine intermediate. | ||
<scene name='Lucas_Hamlow_sandbox_1/Active_sites/1'>The Histidine 246 Residues active in catalysis.</scene> | |||