Fructose Bisphosphate Aldolase: Difference between revisions

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Austin Drake, David Canner, Michal Harel, Alexander Berchansky, Jacob Holt

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 '''Fructose biphosphate aldolase'''
-     Fructose biphosphate aldolase is an enzyme in glycolysis.  It catalyzes the breakdown of fructose-1,6-biophosphate into dihydroxyacetone phosphate (DHAP) and glyceraldehyde-2-phosphate (GAP).  The reaction is an aldol cleavage, or otherwise termed, retro aldo condensation.  Catalysis occurs by the formation of a Schiff base (an imine resulting from a ketone and amine) from the amine of the aldolase's Lys229 and the open-ring form of FBP accompanied by stabilization from Asp33.  <scene name='Austin_Drake_Sandbox/Catalytic_site/1'>Catalytic Site</scene> aldol cleavage produces GAP and an enamine precursor to DHAP.  Tautomerization, protonation and the hydrolysis of the Schiff base produce the final product of DHAP and the active enzyme.
+Fructose biphosphate aldolase is an enzyme in glycolysis.  It catalyzes the breakdown of fructose-1,6-biophosphate into dihydroxyacetone phosphate (DHAP) and glyceraldehyde-2-phosphate (GAP).  The reaction is an aldol cleavage, or otherwise termed, retro aldo condensation.  Catalysis occurs by the formation of a Schiff base (an imine resulting from a ketone and amine) from the amine of the aldolase's Lys229 and the open-ring form of FBP accompanied by stabilization from Asp33.  <scene name='Austin_Drake_Sandbox/Catalytic_site/1'>Catalytic Site</scene> aldol cleavage produces GAP and an enamine precursor to DHAP.  Tautomerization, protonation and the hydrolysis of the Schiff base produce the final product of DHAP and the active enzyme.
 {{STRUCTURE_2ald |  PDB=2ald  |  SCENE=  }}