Group:SMART:2010 Pingry SMART Team: Difference between revisions

Revision as of 08:38, 1 February 2010 view source Caryn Ha (talk \| contribs) 72 edits →‎PDB ID: 1a80, 2,5-diketo-d-gluconic acid reductase with NADPH (wild-type) ← Older edit		Revision as of 08:42, 1 February 2010 view source Caryn Ha (talk \| contribs) 72 edits →‎PDB ID: 1a80, 2,5-diketo-d-gluconic acid reductase with NADPH (wild-type) Newer edit →
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	'''Design description'''		'''Design description'''

	The conformation of 2.5-DKGR A is a parallel alpha/beta barrel of eight <scene name='2010_Pingry_SMART_Team/1a80-default/2'>alpha helices(highlighted red) and eight beta strands(highlighted blue).</scene> Notably, the alpha-beta 8 structure is common among other enzymes of the aldo-keto reductase family.		The conformation of 2.5-DKGR A is a parallel alpha/beta barrel of eight <scene name='2010_Pingry_SMART_Team/1a80-default/2'>alpha helices(highlighted red) and eight beta strands(highlighted blue).</scene> Notably, the alpha-beta 8 structure is common among other enzymes of the aldo-keto reductase family. Located at the C-terminal side of the barrel is the active site for the NADPH cofactor to bind to 2.5-DKGR A.