3isj: Difference between revisions
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{{STRUCTURE_3isj| PDB=3isj | SCENE= }} | {{STRUCTURE_3isj| PDB=3isj | SCENE= }} | ||
===Crystal structure of pantothenate synthetase from Mycobacterium tuberculosis in complex with 5-methoxy-N-(methylsulfonyl)-1H-indole-2-carboxamide=== | ===Crystal structure of pantothenate synthetase from Mycobacterium tuberculosis in complex with 5-methoxy-N-(methylsulfonyl)-1H-indole-2-carboxamide=== | ||
==Function== | |||
[[http://www.uniprot.org/uniprot/PANC_MYCTU PANC_MYCTU]] Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.<ref>PMID:11669627</ref> | |||
==About this Structure== | ==About this Structure== | ||
[[3isj]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ISJ OCA]. | |||
==See Also== | |||
*[[Pantothenate synthetase|Pantothenate synthetase]] | |||
==Reference== | ==Reference== | ||
<ref group="xtra">PMID: | <ref group="xtra">PMID:019780086</ref><references group="xtra"/><references/> | ||
[[Category: Mycobacterium tuberculosis]] | [[Category: Mycobacterium tuberculosis]] | ||
[[Category: Pantoate--beta-alanine ligase]] | [[Category: Pantoate--beta-alanine ligase]] | ||
| Line 27: | Line 22: | ||
[[Category: Wen, S.]] | [[Category: Wen, S.]] | ||
[[Category: Atp-binding]] | [[Category: Atp-binding]] | ||
[[Category: Fragment-based drug design]] | [[Category: Fragment-based drug design]] | ||
[[Category: Ligase]] | [[Category: Ligase]] | ||
| Line 36: | Line 30: | ||
[[Category: Pantothenate biosynthesis]] | [[Category: Pantothenate biosynthesis]] | ||
[[Category: Pantothenate synthetase]] | [[Category: Pantothenate synthetase]] | ||
Revision as of 12:27, 27 March 2013
Crystal structure of pantothenate synthetase from Mycobacterium tuberculosis in complex with 5-methoxy-N-(methylsulfonyl)-1H-indole-2-carboxamideCrystal structure of pantothenate synthetase from Mycobacterium tuberculosis in complex with 5-methoxy-N-(methylsulfonyl)-1H-indole-2-carboxamide
FunctionFunction
[PANC_MYCTU] Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.[1]
About this StructureAbout this Structure
3isj is a 2 chain structure with sequence from Mycobacterium tuberculosis. Full crystallographic information is available from OCA.
See AlsoSee Also
ReferenceReference
- ↑ Hung AW, Silvestre HL, Wen S, Ciulli A, Blundell TL, Abell C. Application of fragment growing and fragment linking to the discovery of inhibitors of Mycobacterium tuberculosis pantothenate synthetase. Angew Chem Int Ed Engl. 2009;48(45):8452-6. PMID:19780086 doi:10.1002/anie.200903821