Group:SMART:2010 Pingry SMART Team: Difference between revisions
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Testosterone (substrate) and NADPH (cofactor) are colored CPK. | Testosterone (substrate) and NADPH (cofactor) are colored CPK. | ||
Non-polar cavity for substrate binding is colored CPK. Leu54, Tyr55, Trp86, Phe118, Phe129, and Tyr216 are hydrophobic amino acids found in the pocket. | <scene name='2010_Pingry_SMART_Team/1lwi_default/5'>Non-polar cavity for substrate binding is colored CPK. Leu54, Tyr55, Trp86, Phe118, Phe129, and Tyr216 are hydrophobic amino acids found in the pocket.</scene> | ||
The catalytic triad is at the distal end of the pocket. | |||
Orange highlights the cofactor specificity sidechains. Gln90, Asn167, Ser166 form hydrogen bonds with the nicotinamide ring. | Orange highlights the cofactor specificity sidechains. Gln90, Asn167, Ser166 form hydrogen bonds with the nicotinamide ring. | ||