1v1o: Difference between revisions
New page: left|200px<br /><applet load="1v1o" size="450" color="white" frame="true" align="right" spinBox="true" caption="1v1o, resolution 2.75Å" /> '''STAPHYLOCOCCAL SUPER... |
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[[Image:1v1o.gif|left|200px]]<br /><applet load="1v1o" size=" | [[Image:1v1o.gif|left|200px]]<br /><applet load="1v1o" size="350" color="white" frame="true" align="right" spinBox="true" | ||
caption="1v1o, resolution 2.75Å" /> | caption="1v1o, resolution 2.75Å" /> | ||
'''STAPHYLOCOCCAL SUPERANTIGEN-LIKE PROTEIN 7'''<br /> | '''STAPHYLOCOCCAL SUPERANTIGEN-LIKE PROTEIN 7'''<br /> | ||
==Overview== | ==Overview== | ||
The staphylococcal superantigen-like proteins (SSLs) are a family of | The staphylococcal superantigen-like proteins (SSLs) are a family of polymorphic paralogs encoded in the Staphylococcus aureus genome whose function is unknown. The crystal structure of SSL7 was determined and compared to that of SSL5 and that of a classical superantigen, streptococcal pyrogenic exotoxin. Although the overall architecture of the superantigen family is retained in both SSL7 and SSL5, there are significant differences in the structures which suggest that the characteristic major histocompatibility complex binding site of superantigens has been lost. To complement these data, the abilities of SSL7 and a closely related paralog, SSL9, to interact with cells of the immune system were investigated. In populations of human white blood cells, both SSLs interacted selectively with monocytes via specific saturable but separate binding sites, which led to rapid uptake of the SSLs. In addition, SSLs were rapidly taken up by dendritic cells, but not by macrophages, into the same endosomal compartment as dextran. The ability of these secreted proteins to target antigen-presenting cells may enhance a misplaced antibody response against the proteins, which may facilitate bacterial colonization rather than contribute to host protection. Like classical superantigens, therefore, SSLs may distract the host's immune system, but they may do so via entirely different molecular mechanisms. | ||
==About this Structure== | ==About this Structure== | ||
1V1O is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http:// | 1V1O is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1V1O OCA]. | ||
==Reference== | ==Reference== | ||
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[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Staphylococcus aureus]] | [[Category: Staphylococcus aureus]] | ||
[[Category: Al-Shangiti, A | [[Category: Al-Shangiti, A M.]] | ||
[[Category: Briggs, D | [[Category: Briggs, D C.]] | ||
[[Category: Nair, S | [[Category: Nair, S P.]] | ||
[[Category: Naylor, C | [[Category: Naylor, C E.]] | ||
[[Category: antigen presenting cell]] | [[Category: antigen presenting cell]] | ||
[[Category: secreted protein]] | [[Category: secreted protein]] | ||
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[[Category: virulence factor]] | [[Category: virulence factor]] | ||
''Page seeded by [http:// | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 15:30:35 2008'' | ||
Revision as of 16:30, 21 February 2008
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STAPHYLOCOCCAL SUPERANTIGEN-LIKE PROTEIN 7
OverviewOverview
The staphylococcal superantigen-like proteins (SSLs) are a family of polymorphic paralogs encoded in the Staphylococcus aureus genome whose function is unknown. The crystal structure of SSL7 was determined and compared to that of SSL5 and that of a classical superantigen, streptococcal pyrogenic exotoxin. Although the overall architecture of the superantigen family is retained in both SSL7 and SSL5, there are significant differences in the structures which suggest that the characteristic major histocompatibility complex binding site of superantigens has been lost. To complement these data, the abilities of SSL7 and a closely related paralog, SSL9, to interact with cells of the immune system were investigated. In populations of human white blood cells, both SSLs interacted selectively with monocytes via specific saturable but separate binding sites, which led to rapid uptake of the SSLs. In addition, SSLs were rapidly taken up by dendritic cells, but not by macrophages, into the same endosomal compartment as dextran. The ability of these secreted proteins to target antigen-presenting cells may enhance a misplaced antibody response against the proteins, which may facilitate bacterial colonization rather than contribute to host protection. Like classical superantigens, therefore, SSLs may distract the host's immune system, but they may do so via entirely different molecular mechanisms.
About this StructureAbout this Structure
1V1O is a Single protein structure of sequence from Staphylococcus aureus. Full crystallographic information is available from OCA.
ReferenceReference
Structural relationships and cellular tropism of staphylococcal superantigen-like proteins., Al-Shangiti AM, Naylor CE, Nair SP, Briggs DC, Henderson B, Chain BM, Infect Immun. 2004 Jul;72(7):4261-70. PMID:15213171
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