1dsm: Difference between revisions

Revision as of 13:19, 21 February 2008

(-)-duocarmycin SA covalently linked to duplex DNA

OverviewOverview

Duocarmycin SA is a member of a growing class of interesting lead compounds for chemotherapy, distinguished by the manner in which they bind to and react with DNA substrates. The first three-dimensional structure of a DNA adduct of an unnatural enantiomer from this family has been determined by (1)H NMR methods. Comparison to the previously determined structure of the natural enantiomer bound in the same DNA-binding site provides unique insights into the similarities and critical distinctions producing the respective alkylation products and site selectivities. The results also support the hypothesis that the duocarmycin SA alkylation reaction is catalyzed by the binding to DNA, and provide a deeper understanding of the structural basis for this unique mode of activation.

About this StructureAbout this Structure

1DSM is a Protein complex structure of sequences from [1] with as ligand. Full crystallographic information is available from OCA.

ReferenceReference

The structural basis for in situ activation of DNA alkylation by duocarmycin SA., Smith JA, Bifulco G, Case DA, Boger DL, Gomez-Paloma L, Chazin WJ, J Mol Biol. 2000 Jul 28;300(5):1195-204. PMID:10903864

Page seeded by OCA on Thu Feb 21 12:19:58 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
-[[Image:1dsm.gif|left|200px]]<br /><applet load="1dsm" size="450" color="white" frame="true" align="right" spinBox="true"
+[[Image:1dsm.gif|left|200px]]<br /><applet load="1dsm" size="350" color="white" frame="true" align="right" spinBox="true"
 caption="1dsm" />
 '''(-)-duocarmycin SA covalently linked to duplex DNA'''<br />
 ==Overview==
-Duocarmycin SA is a member of a growing class of interesting lead, compounds for chemotherapy, distinguished by the manner in which they bind, to and react with DNA substrates. The first three-dimensional structure of, a DNA adduct of an unnatural enantiomer from this family has been, determined by (1)H NMR methods. Comparison to the previously determined, structure of the natural enantiomer bound in the same DNA-binding site, provides unique insights into the similarities and critical distinctions, producing the respective alkylation products and site selectivities. The, results also support the hypothesis that the duocarmycin SA alkylation, reaction is catalyzed by the binding to DNA, and provide a deeper, understanding of the structural basis for this unique mode of activation.
+Duocarmycin SA is a member of a growing class of interesting lead compounds for chemotherapy, distinguished by the manner in which they bind to and react with DNA substrates. The first three-dimensional structure of a DNA adduct of an unnatural enantiomer from this family has been determined by (1)H NMR methods. Comparison to the previously determined structure of the natural enantiomer bound in the same DNA-binding site provides unique insights into the similarities and critical distinctions producing the respective alkylation products and site selectivities. The results also support the hypothesis that the duocarmycin SA alkylation reaction is catalyzed by the binding to DNA, and provide a deeper understanding of the structural basis for this unique mode of activation.
 ==About this Structure==
-DSM is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ] with DSA as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1DSM OCA].
+DSM is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ] with <scene name='pdbligand=DSA:'>DSA</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DSM OCA].
 ==Reference==
 The structural basis for in situ activation of DNA alkylation by duocarmycin SA., Smith JA, Bifulco G, Case DA, Boger DL, Gomez-Paloma L, Chazin WJ, J Mol Biol. 2000 Jul 28;300(5):1195-204. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=10903864 10903864]
 [[Category: Protein complex]]
-[[Category: Case, D.A.]]
+[[Category: Case, D A.]]
-[[Category: Chazin, W.J.]]
+[[Category: Chazin, W J.]]
-[[Category: Smith, J.A.]]
+[[Category: Smith, J A.]]
 [[Category: DSA]]
 [[Category: antitumor agent]]
@@ Line 22: / Line 22: @@
 [[Category: minor groove binding]]
-''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Sun Nov 25 03:37:57 2007''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:19:58 2008''