P53R2: Difference between revisions
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*The blockage of a MAPK pathway | |||
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Experiences from C Piao, M Jin, HB Kim, SM Lee, PN Amatya, J-W Hyun, I-Y Chang and HJ You published in Oncogene 28, show that p53R2 and MEK2 are colocalized in the cytoplasm and that they can bind. This binding is constitutive and depends on the amino acid segment 161 to 206 of p53R2. MEK1 and MEK2 are threonine/tyrosine kinases, they can activate ERK1 and 2 by phosphorylation. The p53R2 regulates negatively the MEK-ERK pathway: it suppresses ERK activation by MEK. p53R2 inhibits tumor cells invasion and metastasis mediated by the blockage of the MEK-ERK pathway and the transcription activity. | Experiences from C Piao, M Jin, HB Kim, SM Lee, PN Amatya, J-W Hyun, I-Y Chang and HJ You published in Oncogene 28, show that p53R2 and MEK2 are colocalized in the cytoplasm and that they can bind. This binding is constitutive and depends on the amino acid segment 161 to 206 of p53R2. MEK1 and MEK2 are threonine/tyrosine kinases, they can activate ERK1 and 2 by phosphorylation. The p53R2 regulates negatively the MEK-ERK pathway: it suppresses ERK activation by MEK. p53R2 inhibits tumor cells invasion and metastasis mediated by the blockage of the MEK-ERK pathway and the transcription activity. | ||
*The DNA repair | |||
The large subunit of the RR: R1 can either interact with R2 or with p53R2 to become catalytically active and produce desoxyribonucleotides for the DNA synthesis. p53R2 is activating by the transcription factor p53. When the cell is stressed, p53 accumulates in the cell and is subjected to post transcriptional modifications which activate the transcription of some genes. This leads to the recruitment of some proteins which will participate to DNA repair. p53R2 helps to repair the DNA by supplying desoxyribonucleotides in a cell where DNA were damaged so it prevents from mutation and cancer. | The large subunit of the RR: R1 can either interact with R2 or with p53R2 to become catalytically active and produce desoxyribonucleotides for the DNA synthesis. p53R2 is activating by the transcription factor p53. When the cell is stressed, p53 accumulates in the cell and is subjected to post transcriptional modifications which activate the transcription of some genes. This leads to the recruitment of some proteins which will participate to DNA repair. p53R2 helps to repair the DNA by supplying desoxyribonucleotides in a cell where DNA were damaged so it prevents from mutation and cancer. | ||
*p53R2 antioxidant activity | |||