3io7: Difference between revisions
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Nov | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Nov 18 17:24:15 2009'' | ||
Revision as of 18:24, 18 November 2009
2-Aminopyrazolo[1,5-a]pyrimidines as potent and selective inhibitors of JAK22-Aminopyrazolo[1,5-a]pyrimidines as potent and selective inhibitors of JAK2
Template:ABSTRACT PUBMED 19857967
DiseaseDisease
Known disease associated with this structure: Leukemia, acute myelogenous OMIM:[147796], Myelofibrosis, idiopathic OMIM:[147796], Myeloproliferative disorder with erythrocytosis OMIM:[147796], Polycythemia vera OMIM:[147796], Thrombocythemia, essential OMIM:[147796], Budd-Chiari syndrome OMIM:[147796]
About this StructureAbout this Structure
3IO7 is a 1 chain structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
ReferenceReference
- ↑ Ledeboer MW, Pierce AC, Duffy JP, Gao H, Messersmith D, Salituro FG, Nanthakumar S, Come J, Zuccola HJ, Swenson L, Shlyakter D, Mahajan S, Hoock T, Fan B, Tsai WJ, Kolaczkowski E, Carrier S, Hogan JK, Zessis R, Pazhanisamy S, Bennani YL. 2-Aminopyrazolo[1,5-a]pyrimidines as potent and selective inhibitors of JAK2. Bioorg Med Chem Lett. 2009 Dec 1;19(23):6529-33. Epub 2009 Oct 24. PMID:19857967 doi:10.1016/j.bmcl.2009.10.053
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Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)
OCACategories:
- Pages with broken file links
- Homo sapiens
- Non-specific protein-tyrosine kinase
- Ledeboer, M W.
- Pierce, A C.
- Zuccola, H J.
- Atp-binding
- Chromosomal rearrangement
- Disease mutation
- Inhibitor
- Jak2
- Janus kinase
- Kinase
- Membrane
- Nucleotide-binding
- Phosphoprotein
- Polymorphism
- Proto-oncogene
- Sh2 domain
- Transferase
- Tyrosine-protein kinase