5cox: Difference between revisions
No edit summary |
No edit summary |
||
| Line 8: | Line 8: | ||
==About this Structure== | ==About this Structure== | ||
5COX is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]] with NAG and HEM as [[http://en.wikipedia.org/wiki/ligands ligands]]. Active as [[http://en.wikipedia.org/wiki/ | 5COX is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]] with NAG and HEM as [[http://en.wikipedia.org/wiki/ligands ligands]]. Active as [[http://en.wikipedia.org/wiki/Prostaglandin-endoperoxide_synthase Prostaglandin-endoperoxide synthase]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.99.1 1.14.99.1]]. Structure known Active Sites: ACE, CAT, HEM and SUB. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=5COX OCA]]. | ||
==Reference== | ==Reference== | ||
Structural basis for selective inhibition of cyclooxygenase-2 by anti-inflammatory agents., Kurumbail RG, Stevens AM, Gierse JK, McDonald JJ, Stegeman RA, Pak JY, Gildehaus D, Miyashiro JM, Penning TD, Seibert K, Isakson PC, Stallings WC, Nature. 1996 Dec 19-26;384(6610):644-8. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=8967954 8967954] | Structural basis for selective inhibition of cyclooxygenase-2 by anti-inflammatory agents., Kurumbail RG, Stevens AM, Gierse JK, McDonald JJ, Stegeman RA, Pak JY, Gildehaus D, Miyashiro JM, Penning TD, Seibert K, Isakson PC, Stallings WC, Nature. 1996 Dec 19-26;384(6610):644-8. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=8967954 8967954] | ||
[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
[[Category: Prostaglandin-endoperoxide synthase]] | |||
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Kurumbail, R.]] | [[Category: Kurumbail, R.]] | ||
| Line 28: | Line 29: | ||
[[Category: prostaglandin synthase]] | [[Category: prostaglandin synthase]] | ||
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 10:44:30 2007'' | ||
Revision as of 11:39, 30 October 2007
|
UNINHIBITED MOUSE CYCLOOXYGENASE-2 (PROSTAGLANDIN SYNTHASE-2)
OverviewOverview
Prostaglandins and glucocorticoids are potent mediators of inflammation., Non-steroidal anti-inflammatory drugs (NSAIDs) exert their effects by, inhibition of prostaglandin production. The pharmacological target of, NSAIDs is cyclooxygenase (COX, also known as PGH synthase), which, catalyses the first committed step in arachidonic-acid metabolism. Two, isoforms of the membrane protein COX are known: COX-1, which is, constitutively expressed in most tissues, is responsible for the, physiological production of prostaglandins; and COX-2, which is induced by, cytokines, mitogens and endotoxins in inflammatory cells, is responsible, for the elevated production of prostaglandins during inflammation. The, structure of ovine COX-1 complexed with several NSAIDs has been, determined. Here we report ... [(full description)]
About this StructureAbout this Structure
5COX is a [Single protein] structure of sequence from [Mus musculus] with NAG and HEM as [ligands]. Active as [Prostaglandin-endoperoxide synthase], with EC number [1.14.99.1]. Structure known Active Sites: ACE, CAT, HEM and SUB. Full crystallographic information is available from [OCA].
ReferenceReference
Structural basis for selective inhibition of cyclooxygenase-2 by anti-inflammatory agents., Kurumbail RG, Stevens AM, Gierse JK, McDonald JJ, Stegeman RA, Pak JY, Gildehaus D, Miyashiro JM, Penning TD, Seibert K, Isakson PC, Stallings WC, Nature. 1996 Dec 19-26;384(6610):644-8. PMID:8967954
Page seeded by OCA on Tue Oct 30 10:44:30 2007