1le0: Difference between revisions
New page: left|200px<br /><applet load="1le0" size="450" color="white" frame="true" align="right" spinBox="true" caption="1le0" /> '''NMR structure of Tryptophan Zipper 1: a stab... |
No edit summary |
||
| Line 1: | Line 1: | ||
[[Image:1le0.jpg|left|200px]]<br /><applet load="1le0" size=" | [[Image:1le0.jpg|left|200px]]<br /><applet load="1le0" size="350" color="white" frame="true" align="right" spinBox="true" | ||
caption="1le0" /> | caption="1le0" /> | ||
'''NMR structure of Tryptophan Zipper 1: a stable, monomeric beta-hairpin with a type II' turn'''<br /> | '''NMR structure of Tryptophan Zipper 1: a stable, monomeric beta-hairpin with a type II' turn'''<br /> | ||
==Overview== | ==Overview== | ||
A structural motif, the tryptophan zipper (trpzip), greatly stabilizes the | A structural motif, the tryptophan zipper (trpzip), greatly stabilizes the beta-hairpin conformation in short peptides. Peptides (12 or 16 aa in length) with four different turn sequences are monomeric and fold cooperatively in water, as has been observed previously for some hairpin peptides. However, the folding free energies of the trpzips exceed substantially those of all previously reported beta-hairpins and even those of some larger designed proteins. NMR structures of three of the trpzip peptides reveal exceptionally well-defined beta-hairpin conformations stabilized by cross-strand pairs of indole rings. The trpzips are the smallest peptides to adopt an unique tertiary fold without requiring metal binding, unusual amino acids, or disulfide crosslinks. | ||
==About this Structure== | ==About this Structure== | ||
1LE0 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ] with NH2 as [http://en.wikipedia.org/wiki/ligand ligand]. This structure | 1LE0 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ] with <scene name='pdbligand=NH2:'>NH2</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. This structure supersedes the now removed PDB entry 1HRW. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LE0 OCA]. | ||
==Reference== | ==Reference== | ||
Tryptophan zippers: stable, monomeric beta -hairpins., Cochran AG, Skelton NJ, Starovasnik MA, Proc Natl Acad Sci U S A. 2001 May 8;98(10):5578-83. Epub 2001 May 1. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=11331745 11331745] | Tryptophan zippers: stable, monomeric beta -hairpins., Cochran AG, Skelton NJ, Starovasnik MA, Proc Natl Acad Sci U S A. 2001 May 8;98(10):5578-83. Epub 2001 May 1. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=11331745 11331745] | ||
[[Category: Protein complex]] | [[Category: Protein complex]] | ||
[[Category: Cochran, A | [[Category: Cochran, A G.]] | ||
[[Category: Skelton, N | [[Category: Skelton, N J.]] | ||
[[Category: Starovasnik, M | [[Category: Starovasnik, M A.]] | ||
[[Category: NH2]] | [[Category: NH2]] | ||
[[Category: beta-hairpin]] | [[Category: beta-hairpin]] | ||
[[Category: type ii' turn]] | [[Category: type ii' turn]] | ||
''Page seeded by [http:// | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:44:05 2008'' | ||
