Nobel Prizes for 3D Molecular Structure: Difference between revisions
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* 2006: [http://nobelprize.org/nobel_prizes/chemistry/laureates/2006/index.html Roger Kornberg] (Chemistry) "for his studies of the molecular basis of eukaryotic transcription". Kornberg and his group solved the structure of DNA-dependent '''RNA polymerase'''. In 1959, Roger saw his father Arthur Kornberg receive the Nobel Prize in Physiology or Medicine, with Severo Ochoa, for discovering DNA polymerase and describing the mechanism of DNA replication. The first RNA polymerase structures, from early 2001: [[1i3q]], [[1i50]], [[1i6h]], followed by others. | * 2006: [http://nobelprize.org/nobel_prizes/chemistry/laureates/2006/index.html Roger Kornberg] (Chemistry) "for his studies of the molecular basis of eukaryotic transcription". Kornberg and his group solved the structure of DNA-dependent '''RNA polymerase'''. In 1959, Roger saw his father Arthur Kornberg receive the Nobel Prize in Physiology or Medicine, with Severo Ochoa, for discovering DNA polymerase and describing the mechanism of DNA replication. The first RNA polymerase structures, from early 2001: [[1i3q]], [[1i50]], [[1i6h]], followed by others. | ||
* 2009: [http://nobelprize.org/nobel_prizes/chemistry/laureates/2009/index.html Venkatraman Ramakrishnan, Thomas A. Steitz, and Ada E. Yonath] (Chemistry) "for studies of the structure and function of the ribosome". The structure of the ribosome, published in 2000, revealed that the peptidyl transferase is a ribozyme, rather than a protein enzyme, despite protein comprising 40-50% of ribosomal mass. A 2.4 Å structure of the large (50S) subunit from ''Haloarcula marismortui'', [[1ffk]], was published in ''Science'' by the Steitz group (Yale University, New Haven, CT, USA) in August, 2000. One month later appeared in ''Nature'' a 3.0 Å structure of the small (30S) subunit, [[1fjg]], from the Ramakrishnan group (MRC Laboratory of Molecular Biology, Cambridge, United Kingdom), and in ''Cell'' a 3.3 Å structure of the small subunit, [[1fka]], by the Yonath group (Weizmann Institute of Science, Rehovot, Israel). Less than a year later appeared in ''Science'' a 5.5 Å structure of the entire ribosome, [[1gix]] plus [[1giy]], from the group of Harry F. Noller (University of California, Santa Cruz). All were from ''Thermus thermophilus'', with the exception of the Steitz group's structure; all were from [[extremophiles]]. In subsequent years, these and other groups contributed many more highly informative structures (some are listed at [[Ribosome]]). | * 2009: [http://nobelprize.org/nobel_prizes/chemistry/laureates/2009/index.html Venkatraman Ramakrishnan, Thomas A. Steitz, and Ada E. Yonath] (Chemistry) "for studies of the structure and function of the ribosome". The structure of the ribosome, published in 2000, revealed that the peptidyl transferase is a ribozyme, rather than a protein enzyme, despite protein comprising 40-50% of ribosomal mass. A 2.4 Å structure of the large (50S) subunit from ''Haloarcula marismortui'', [[1ffk]], was published in ''Science'' by the Steitz group (Yale University, New Haven, CT, USA) in August, 2000. One month later appeared in ''Nature'' a 3.0 Å structure of the small (30S) subunit, [[1fjg]], from the Ramakrishnan group (MRC Laboratory of Molecular Biology, Cambridge, United Kingdom), and in ''Cell'' a 3.3 Å structure of the small subunit, [[1fka]], by the Yonath group (Weizmann Institute of Science, Rehovot, Israel). Less than a year later appeared in ''Science'' a 5.5 Å structure of the entire ribosome, [[1gix]] plus [[1giy]], from the group of Harry F. Noller (University of California, Santa Cruz). All were from ''Thermus thermophilus'', with the exception of the Steitz group's structure; all were from [[extremophiles]]. In subsequent years, these and other groups contributed many more highly informative structures (some are listed at [[Ribosome|the ribosome entry]]). | ||
** [http://www.pdb.org/pdb/static.do?p=general_information/news_publications/news/news_2009.html#20091013 Announcement at the RCSB PDB]. | ** [http://www.pdb.org/pdb/static.do?p=general_information/news_publications/news/news_2009.html#20091013 Announcement at the RCSB PDB]. | ||
** [http://www.nigms.nih.gov/News/Results/nobel_20091007a.htm Three NIGMS Grantees Receive Nobel Prize in Chemistry for Ribosome Research]. | ** [http://www.nigms.nih.gov/News/Results/nobel_20091007a.htm Three NIGMS Grantees Receive Nobel Prize in Chemistry for Ribosome Research]. | ||
** [[Ribosome]] in Proteopedia. | ** [[Ribosome|The Ribosome]] in Proteopedia. | ||
** [http://www.pdb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb10_1.html October 2000 Molecule of the Month]. | ** [http://www.pdb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb10_1.html October 2000 Molecule of the Month]. | ||
** [[Highest_impact_structures|Highest Impact Structures of All Time]]. | ** [[Highest_impact_structures|Highest Impact Structures of All Time]]. | ||