M2 Proton Channel: Difference between revisions

The M2 proton channel is a key protein that leads to viral infection [Takeuchi et al]. The M2 proton channel acidifies the viron which allows the viral matrix protein (M1) to disassociate from the ribonucleoprotein (RNP) [wu et al]. This allows the RNP to be transported to the nucleus of the cell [wu et al]. Several recent studies have looked at the effects of <scene name='User:Sarah_Henke/Sandbox_1/Amantadine/1'>amantadine</scene> <ref>PMID:12403618</ref> and <scene name='User:Sarah_Henke/Sandbox_1/Rimantadine/1'>rimantadine</scene> [Schnell et al] on inhibiting the transfer of protons through the M2 channel <ref name="Stouffer" />. It has been found that M2 is resistant to these two drugs in 90% of humans, birds and pigs <ref>PMID:12403618</ref>. Understanding the structure and function of this proton channel is necessary in solving the resistance problem <ref name="Stouffer" />.