2kkc: Difference between revisions

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-{{Seed}}
-[[Image:2kkc.jpg|left|200px]]
-<!--
+==NMR structure of the p62 PB1 domain==
-The line below this paragraph, containing "STRUCTURE_2kkc", creates the "Structure Box" on the page.
+<StructureSection load='2kkc' size='340' side='right'caption='[[2kkc]]' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[2kkc]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KKC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KKC FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
--->
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kkc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kkc OCA], [https://pdbe.org/2kkc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kkc RCSB], [https://www.ebi.ac.uk/pdbsum/2kkc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kkc ProSAT]</span></td></tr>
-{{STRUCTURE_2kkc|  PDB=2kkc  |  SCENE=  }}
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/SQSTM_RAT SQSTM_RAT] Required both for the formation and autophagic degradation of polyubiquitin-containing bodies, called ALIS (aggresome-like induced structures). Links ALIS to the autophagic machinery via direct interaction with MAP1 LC3 family members (By similarity). May regulate the activation of NFKB1 by TNF-alpha, nerve growth factor (NGF) and interleukin-1. Adapter that mediates the interaction between TRAF6 and CYLD (By similarity). May play a role in titin/TTN downstream signaling in muscle cells. May regulate signaling cascades through ubiquitination. May be involved in cell differentiation, apoptosis, immune response and regulation of K(+) channels. Isoform 1 is more potent than isoform 2 to stimulate PRKCZ-dependent phosphorylation of KCNAB2.<ref>PMID:10477520</ref> <ref>PMID:11244088</ref> <ref>PMID:11500922</ref>
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kk/2kkc_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2kkc ConSurf].
+<div style="clear:both"></div>
-===NMR structure of the p62 PB1 domain===
+==See Also==
+*[[Sequestosome|Sequestosome]]
+== References ==
-==About this Structure==
+<references/>
-KKC is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KKC OCA].
+__TOC__
+</StructureSection>
-==Reference==
+[[Category: Large Structures]]
-<ref group="xtra">PMID:19728111</ref><references group="xtra"/>
 [[Category: Rattus norvegicus]]
-[[Category: Inagaki, F.]]
+[[Category: Inagaki F]]
-[[Category: Yokochi, M.]]
+[[Category: Yokochi M]]
-[[Category: Alternative splicing]]
-[[Category: Apoptosis]]
-[[Category: Autophagy]]
-[[Category: Cytoplasm]]
-[[Category: Differentiation]]
-[[Category: Endosome]]
-[[Category: Immune response]]
-[[Category: Metal-binding]]
-[[Category: Nf-kb signaling]]
-[[Category: Nucleus]]
-[[Category: P62]]
-[[Category: Pb1]]
-[[Category: Phosphoprotein]]
-[[Category: Signaling protein]]
-[[Category: Transport protein]]
-[[Category: Ubiquitin-proteasome system]]
-[[Category: Zinc]]
-[[Category: Zinc-finger]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Sep 16 08:57:49 2009''