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[[Image:2jkv.jpg|left|200px]]


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==Structure of human Phosphogluconate Dehydrogenase in complex with NADPH at 2.53A==
The line below this paragraph, containing "STRUCTURE_2jkv", creates the "Structure Box" on the page.
<StructureSection load='2jkv' size='340' side='right'caption='[[2jkv]], [[Resolution|resolution]] 2.53&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[2jkv]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JKV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JKV FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.532&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
{{STRUCTURE_2jkv| PDB=2jkv |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jkv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jkv OCA], [https://pdbe.org/2jkv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jkv RCSB], [https://www.ebi.ac.uk/pdbsum/2jkv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jkv ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/6PGD_HUMAN 6PGD_HUMAN] Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jk/2jkv_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2jkv ConSurf].
<div style="clear:both"></div>


===STRUCTURE OF HUMAN PHOSPHOGLUCONATE DEHYDROGENASE IN COMPLEX WITH NADPH AT 2.53A===
==See Also==
 
*[[6-phosphogluconate dehydrogenase 3D structures|6-phosphogluconate dehydrogenase 3D structures]]
 
__TOC__
==About this Structure==
</StructureSection>
2JKV is a 6 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JKV OCA].
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Arrowsmith, C H.]]
[[Category: Large Structures]]
[[Category: Bountra, C.]]
[[Category: Arrowsmith CH]]
[[Category: Delft, F Von.]]
[[Category: Bountra C]]
[[Category: Edwards, A.]]
[[Category: Edwards A]]
[[Category: Guo, K.]]
[[Category: Guo K]]
[[Category: Kavanagh, K L.]]
[[Category: Kavanagh KL]]
[[Category: Muniz, J R.C.]]
[[Category: Muniz JRC]]
[[Category: Murray, J.]]
[[Category: Murray J]]
[[Category: Oppermann, U.]]
[[Category: Oppermann U]]
[[Category: Picaud, S.]]
[[Category: Picaud S]]
[[Category: Pilka, E S.]]
[[Category: Pilka ES]]
[[Category: Weigelt, J.]]
[[Category: Weigelt J]]
[[Category: Dehydrogenase]]
[[Category: Von Delft F]]
[[Category: Nadp]]
[[Category: Nadph]]
[[Category: Oxidoreductase]]
[[Category: Pentose shunt]]
[[Category: Phosphogluconate]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Sep  3 16:05:31 2009''

Latest revision as of 17:53, 13 December 2023

Structure of human Phosphogluconate Dehydrogenase in complex with NADPH at 2.53AStructure of human Phosphogluconate Dehydrogenase in complex with NADPH at 2.53A

Structural highlights

2jkv is a 6 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.532Å
Ligands:, ,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

6PGD_HUMAN Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH.

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

2jkv, resolution 2.53Å

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