3ii6: Difference between revisions

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-{{Seed}}
-[[Image:3ii6.jpg|left|200px]]
-<!--
+==Structure of human Xrcc4 in complex with the tandem BRCT domains of DNA LigaseIV.==
-The line below this paragraph, containing "STRUCTURE_3ii6", creates the "Structure Box" on the page.
+<StructureSection load='3ii6' size='340' side='right'caption='[[3ii6]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[3ii6]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3II6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3II6 FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
--->
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
-{{STRUCTURE_3ii6|  PDB=3ii6  |  SCENE=  }}
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ii6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ii6 OCA], [https://pdbe.org/3ii6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ii6 RCSB], [https://www.ebi.ac.uk/pdbsum/3ii6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ii6 ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/XRCC4_HUMAN XRCC4_HUMAN] Involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination. Binds to DNA and to DNA ligase IV (LIG4). The LIG4-XRCC4 complex is responsible for the NHEJ ligation step, and XRCC4 enhances the joining activity of LIG4. Binding of the LIG4-XRCC4 complex to DNA ends is dependent on the assembly of the DNA-dependent protein kinase complex DNA-PK to these DNA ends.<ref>PMID:8548796</ref> <ref>PMID:10854421</ref> <ref>PMID:10757784</ref> <ref>PMID:16412978</ref>
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ii/3ii6_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3ii6 ConSurf].
+<div style="clear:both"></div>
-===Structure of human Xrcc4 in complex with the tandem BRCT domains of DNA LigaseIV.===
+==See Also==
+*[[DNA ligase 3D structures|DNA ligase 3D structures]]
+== References ==
-<!--
+<references/>
-The line below this paragraph, {{ABSTRACT_PUBMED_19332554}}, adds the Publication Abstract to the page
+__TOC__
-(as it appears on PubMed at http://www.pubmed.gov), where 19332554 is the PubMed ID number.
+</StructureSection>
--->
-{{ABSTRACT_PUBMED_19332554}}
-==Disease==
-Known disease associated with this structure: LIG4 syndrome OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=601837 601837]], Multiple myeloma, resistance to OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=601837 601837]]
-==About this Structure==
-II6 is a 6 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3II6 OCA].
-==Reference==
-<ref group="xtra">PMID:19332554</ref><references group="xtra"/>
 [[Category: Homo sapiens]]
-[[Category: Junop, M.]]
+[[Category: Large Structures]]
-[[Category: Meesala, S.]]
+[[Category: Junop M]]
-[[Category: Alternative splicing]]
+[[Category: Meesala S]]
-[[Category: Atp-binding]]
-[[Category: Brct]]
-[[Category: Cell cycle]]
-[[Category: Cell division]]
-[[Category: Coiled coil]]
-[[Category: Disease mutation]]
-[[Category: Dna damage]]
-[[Category: Dna ligase iv]]
-[[Category: Dna recombination]]
-[[Category: Dna repair]]
-[[Category: Dna replication]]
-[[Category: Isopeptide bond]]
-[[Category: Ligase]]
-[[Category: Ligase/dna binding protein complex]]
-[[Category: Magnesium]]
-[[Category: Metal-binding]]
-[[Category: Nhej]]
-[[Category: Nucleotide-binding]]
-[[Category: Nucleus]]
-[[Category: Phosphoprotein]]
-[[Category: Polymorphism]]
-[[Category: Scid]]
-[[Category: Ubl conjugation]]
-[[Category: Xrcc4]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Aug 12 13:49:35 2009''