1nqy: Difference between revisions

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New page: left|200px<br /><applet load="1nqy" size="450" color="white" frame="true" align="right" spinBox="true" caption="1nqy, resolution 2.09Å" /> '''The structure of a C...
 
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[[Image:1nqy.jpg|left|200px]]<br /><applet load="1nqy" size="450" color="white" frame="true" align="right" spinBox="true"
caption="1nqy, resolution 2.09&Aring;" />
'''The structure of a CoA pyrophosphatase from D. Radiodurans'''<br />


==Overview==
==The structure of a CoA pyrophosphatase from D. Radiodurans==
Gene Dr1184 from Deinococcus radiodurans codes for a Nudix enzyme, (DR-CoAse) that hydrolyzes the pyrophosphate moiety of coenzyme A (CoA)., Nudix enzymes with the same specificity have been found in yeast, humans, and mice. The three-dimensional structure of DR-CoAse, the first of a, Nudix hydrolase with this specificity, reveals that this enzyme contains, in addition to the fold observed in other Nudix enzymes, insertions that, are characteristic of a CoA-hydrolyzing Nudix subfamily. The structure of, the complex of the enzyme with Mg(2+), its activating cation, reveals the, position of the catalytic site. A helix, part of the N-terminal insertion, partially occludes the binding site and has to change its position to, permit substrate binding. Comparison of the structure of DR-CoAse to those, of other Nudix enzymes, together with the location in the structure of the, sequence characteristic of CoAses, suggests a mode of binding of the, substrate to the enzyme that is compatible with all available data.
<StructureSection load='1nqy' size='340' side='right'caption='[[1nqy]], [[Resolution|resolution]] 2.09&Aring;' scene=''>
 
== Structural highlights ==
==About this Structure==
<table><tr><td colspan='2'>[[1nqy]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Deinococcus_radiodurans Deinococcus radiodurans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NQY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1NQY FirstGlance]. <br>
1NQY is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Deinococcus_radiodurans Deinococcus radiodurans]. Active as [http://en.wikipedia.org/wiki/Nucleotide_diphosphatase Nucleotide diphosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.1.9 3.6.1.9] Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1NQY OCA].  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.09&#8491;</td></tr>
 
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1nqy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nqy OCA], [https://pdbe.org/1nqy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1nqy RCSB], [https://www.ebi.ac.uk/pdbsum/1nqy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1nqy ProSAT]</span></td></tr>
==Reference==
</table>
Structure of a coenzyme A pyrophosphatase from Deinococcus radiodurans: a member of the Nudix family., Kang LW, Gabelli SB, Bianchet MA, Xu WL, Bessman MJ, Amzel LM, J Bacteriol. 2003 Jul;185(14):4110-8. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=12837785 12837785]
== Function ==
[https://www.uniprot.org/uniprot/Y1184_DEIRA Y1184_DEIRA]
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/nq/1nqy_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1nqy ConSurf].
<div style="clear:both"></div>
__TOC__
</StructureSection>
[[Category: Deinococcus radiodurans]]
[[Category: Deinococcus radiodurans]]
[[Category: Nucleotide diphosphatase]]
[[Category: Large Structures]]
[[Category: Single protein]]
[[Category: Amzel LM]]
[[Category: Amzel, L.M.]]
[[Category: Bessman MJ]]
[[Category: Bessman, M.J.]]
[[Category: Bianchet MA]]
[[Category: Bianchet, M.A.]]
[[Category: Gabelli SB]]
[[Category: Gabelli, S.B.]]
[[Category: Kang LW]]
[[Category: Kang, L.W.]]
[[Category: Xu WL]]
[[Category: Xu, W.L.]]
[[Category: coa]]
[[Category: dr1184]]
[[Category: nudix]]
[[Category: pyrophosphatase]]
 
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Sat Nov 24 23:36:30 2007''

Latest revision as of 10:59, 14 February 2024

The structure of a CoA pyrophosphatase from D. RadioduransThe structure of a CoA pyrophosphatase from D. Radiodurans

Structural highlights

1nqy is a 1 chain structure with sequence from Deinococcus radiodurans. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.09Å
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

Y1184_DEIRA

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

1nqy, resolution 2.09Å

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA
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