3fhb: Difference between revisions

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-{{Seed}}
-[[Image:3fhb.png|left|200px]]
-<!--
+==Human poly(ADP-ribose) polymerase 3, catalytic fragment in complex with an inhibitor 3-aminobenzoic acid==
-The line below this paragraph, containing "STRUCTURE_3fhb", creates the "Structure Box" on the page.
+<StructureSection load='3fhb' size='340' side='right'caption='[[3fhb]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[3fhb]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2pa9 2pa9]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FHB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3FHB FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
--->
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GAB:3-AMINOBENZOIC+ACID'>GAB</scene></td></tr>
-{{STRUCTURE_3fhb|  PDB=3fhb  |  SCENE=  }}
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3fhb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fhb OCA], [https://pdbe.org/3fhb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3fhb RCSB], [https://www.ebi.ac.uk/pdbsum/3fhb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3fhb ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/PARP3_HUMAN PARP3_HUMAN] Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. May link the DNA damage surveillance network to the mitotic fidelity checkpoint. Negatively influences the G1/S cell cycle progression without interfering with centrosome duplication. Binds DNA. May be involved in the regulation of PRC2 and PRC3 complex-dependent gene silencing.<ref>PMID:16924674</ref>
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fh/3fhb_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3fhb ConSurf].
+<div style="clear:both"></div>
-===Human poly(ADP-ribose) polymerase 3, catalytic fragment in complex with an inhibitor 3-aminobenzoic acid===
+==See Also==
+*[[Poly(ADP-ribose) polymerase 3D structures|Poly(ADP-ribose) polymerase 3D structures]]
+== References ==
-<!--
+<references/>
-The line below this paragraph, {{ABSTRACT_PUBMED_19354255}}, adds the Publication Abstract to the page
+__TOC__
-(as it appears on PubMed at http://www.pubmed.gov), where 19354255 is the PubMed ID number.
+</StructureSection>
--->
-{{ABSTRACT_PUBMED_19354255}}
-==About this Structure==
-FHB is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2pa9 2pa9]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FHB OCA].
-==Reference==
-<ref group="xtra">PMID:19354255</ref><references group="xtra"/>
 [[Category: Homo sapiens]]
-[[Category: Arrowsmith, C H.]]
+[[Category: Large Structures]]
-[[Category: Berg, S Van Den.]]
+[[Category: Arrowsmith CH]]
-[[Category: Berglund, H.]]
+[[Category: Berglund H]]
-[[Category: Busam, R.]]
+[[Category: Busam R]]
-[[Category: Collins, R.]]
+[[Category: Collins R]]
-[[Category: Dahlgren, L G.]]
+[[Category: Dahlgren LG]]
-[[Category: Edwards, A M.]]
+[[Category: Edwards AM]]
-[[Category: Flodin, S.]]
+[[Category: Flodin S]]
-[[Category: Flores, A.]]
+[[Category: Flores A]]
-[[Category: Graslund, S.]]
+[[Category: Graslund S]]
-[[Category: Hallberg, B M.]]
+[[Category: Hallberg BM]]
-[[Category: Hammarstrom, M.]]
+[[Category: Hammarstrom M]]
-[[Category: Holmberg-Schiavone, L.]]
+[[Category: Holmberg-Schiavone L]]
-[[Category: Johansson, I.]]
+[[Category: Johansson I]]
-[[Category: Karlberg, T.]]
+[[Category: Karlberg T]]
-[[Category: Kotenyova, T.]]
+[[Category: Kotenyova T]]
-[[Category: Lehtio, L.]]
+[[Category: Lehtio L]]
-[[Category: Moche, M.]]
+[[Category: Moche M]]
-[[Category: Nordlund, P.]]
+[[Category: Nordlund P]]
-[[Category: Nyman, T.]]
+[[Category: Nyman T]]
-[[Category: Ogg, D.]]
+[[Category: Ogg D]]
-[[Category: Persson, C.]]
+[[Category: Persson C]]
-[[Category: SGC, Structural Genomics Consortium.]]
+[[Category: Sagemark J]]
-[[Category: Sagemark, J.]]
+[[Category: Schueler H]]
-[[Category: Schueler, H.]]
+[[Category: Stenmark P]]
-[[Category: Stenmark, P.]]
+[[Category: Sundstrom M]]
-[[Category: Sundstrom, M.]]
+[[Category: Thorsell AG]]
-[[Category: Thorsell, A G.]]
+[[Category: Van Den Berg S]]
-[[Category: Weigelt, J.]]
+[[Category: Weigelt J]]
-[[Category: Alternative splicing]]
-[[Category: Catalytic fragment]]
-[[Category: Enzyme-inhibitor complex]]
-[[Category: Glycosyltransferase]]
-[[Category: Nad]]
-[[Category: Nucleus]]
-[[Category: Sgc]]
-[[Category: Structural genomic]]
-[[Category: Structural genomics consortium]]
-[[Category: Transferase]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jun 17 09:22:09 2009''