3ea2: Difference between revisions

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{{Seed}}
[[Image:3ea2.png|left|200px]]


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==Crystal Structure of the Myo-inositol bound Y247S/Y251S Mutant of Phosphatidylinositol-Specific Phospholipase C from Bacillus Thuringiensis==
The line below this paragraph, containing "STRUCTURE_3ea2", creates the "Structure Box" on the page.
<StructureSection load='3ea2' size='340' side='right'caption='[[3ea2]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)  
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[3ea2]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_thuringiensis Bacillus thuringiensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EA2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3EA2 FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.95&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=INS:1,2,3,4,5,6-HEXAHYDROXY-CYCLOHEXANE'>INS</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
{{STRUCTURE_3ea2| PDB=3ea2 |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ea2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ea2 OCA], [https://pdbe.org/3ea2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ea2 RCSB], [https://www.ebi.ac.uk/pdbsum/3ea2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ea2 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/PLC_BACTU PLC_BACTU] Cleaves glycosylphosphatidylinositol (GPI) and phosphatidylinositol (PI) anchors but not PI phosphates.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ea/3ea2_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3ea2 ConSurf].
<div style="clear:both"></div>


===Crystal Structure of the Myo-inositol bound Y247S/Y251S Mutant of Phosphatidylinositol-Specific Phospholipase C from Bacillus Thuringiensis===
==See Also==
 
*[[Phospholipase C|Phospholipase C]]
 
__TOC__
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</StructureSection>
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(as it appears on PubMed at http://www.pubmed.gov), where 19369255 is the PubMed ID number.
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{{ABSTRACT_PUBMED_19369255}}
 
==About this Structure==
3EA2 is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Bacillus_thuringiensis Bacillus thuringiensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EA2 OCA].
 
==Reference==
<ref group="xtra">PMID:19369255</ref><references group="xtra"/>
[[Category: Bacillus thuringiensis]]
[[Category: Bacillus thuringiensis]]
[[Category: Phosphatidylinositol diacylglycerol-lyase]]
[[Category: Large Structures]]
[[Category: Head, J F.]]
[[Category: Head JF]]
[[Category: Redfied, A G.]]
[[Category: Redfied AG]]
[[Category: Roberts, M F.]]
[[Category: Roberts MF]]
[[Category: Seaton, B A.]]
[[Category: Seaton BA]]
[[Category: Shao, C.]]
[[Category: Shao C]]
[[Category: Shi, X.]]
[[Category: Shi X]]
[[Category: Zambonelli, C.]]
[[Category: Zambonelli C]]
[[Category: Zhang, X.]]
[[Category: Zhang X]]
[[Category: Dimer]]
[[Category: Interfacially impaired]]
[[Category: Lipid degradation]]
[[Category: Lyase]]
[[Category: Membrane binding]]
[[Category: Myo-inositol]]
[[Category: Phosphatidylinositol-specific phospholipase c]]
[[Category: Pi-plc]]
[[Category: Secreted]]
[[Category: Tim barrel]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jun 10 18:20:33 2009''

Latest revision as of 12:46, 21 February 2024

Crystal Structure of the Myo-inositol bound Y247S/Y251S Mutant of Phosphatidylinositol-Specific Phospholipase C from Bacillus ThuringiensisCrystal Structure of the Myo-inositol bound Y247S/Y251S Mutant of Phosphatidylinositol-Specific Phospholipase C from Bacillus Thuringiensis

Structural highlights

3ea2 is a 2 chain structure with sequence from Bacillus thuringiensis. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.95Å
Ligands:,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

PLC_BACTU Cleaves glycosylphosphatidylinositol (GPI) and phosphatidylinositol (PI) anchors but not PI phosphates.

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

3ea2, resolution 1.95Å

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