1mi7: Difference between revisions

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[[Image:1mi7.png|left|200px]]


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==Crystal Structure of Domain Swapped trp Aporepressor in 30%(v/v) Isopropanol==
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<StructureSection load='1mi7' size='340' side='right'caption='[[1mi7]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1mi7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MI7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1MI7 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IPA:ISOPROPYL+ALCOHOL'>IPA</scene></td></tr>
{{STRUCTURE_1mi7|  PDB=1mi7  |  SCENE=  }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1mi7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mi7 OCA], [https://pdbe.org/1mi7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1mi7 RCSB], [https://www.ebi.ac.uk/pdbsum/1mi7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1mi7 ProSAT]</span></td></tr>
 
</table>
===Crystal Structure of Domain Swapped trp Aporepressor in 30%(v/v) Isopropanol===
== Function ==
 
[https://www.uniprot.org/uniprot/TRPR_ECOLI TRPR_ECOLI] This protein is an aporepressor. When complexed with L-tryptophan it binds the operator region of the trp operon (5'-ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region.
 
== Evolutionary Conservation ==
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    <text>to colour the structure by Evolutionary Conservation</text>
==About this Structure==
  </jmolCheckbox>
1MI7 is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MI7 OCA].  
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1mi7 ConSurf].
 
<div style="clear:both"></div>
==Reference==
__TOC__
<ref group="xtra">PMID:15274929</ref><references group="xtra"/>
</StructureSection>
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
[[Category: Benoff, B.]]
[[Category: Large Structures]]
[[Category: Berger, T.]]
[[Category: Benoff B]]
[[Category: Berman, H M.]]
[[Category: Berger T]]
[[Category: Carey, J.]]
[[Category: Berman HM]]
[[Category: Lawson, C L.]]
[[Category: Carey J]]
[[Category: Alcohol induced conformational rearrangement]]
[[Category: Lawson CL]]
[[Category: Dna binding protein]]
[[Category: Domain swapping]]
[[Category: Transcription]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jun 10 18:13:01 2009''

Latest revision as of 10:44, 14 February 2024

Crystal Structure of Domain Swapped trp Aporepressor in 30%(v/v) IsopropanolCrystal Structure of Domain Swapped trp Aporepressor in 30%(v/v) Isopropanol

Structural highlights

1mi7 is a 1 chain structure with sequence from Escherichia coli. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.5Å
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

TRPR_ECOLI This protein is an aporepressor. When complexed with L-tryptophan it binds the operator region of the trp operon (5'-ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region.

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

1mi7, resolution 2.50Å

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