1e9w: Difference between revisions

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-[[Image:1e9w.gif|left|200px]]<br /><applet load="1e9w" size="450" color="white" frame="true" align="right" spinBox="true"
-caption="1e9w, resolution 1.02&Aring;" />
-'''STRUCTURE OF THE MACROCYCLE THIOSTREPTON SOLVED USING THE ANOMALOUS DISPERSIVE CONTRIBUTION FROM SULFUR'''<br />
-==Overview==
+==Structure of the macrocycle thiostrepton solved using the anomalous dispersive contribution from sulfur==
-The structure of a tetragonal crystal form of thiostrepton has been solved, using the anomalous dispersive effects of five S atoms from, high-redundancy data collected to 1.33 A resolution at the Cu Kalpha, wavelength. Data measured to 1.02 A resolution with a synchrotron source, were used for refinement. Details of the molecular structure, intramolecular and intermolecular interactions are given.
+<StructureSection load='1e9w' size='340' side='right'caption='[[1e9w]], [[Resolution|resolution]] 1.02&Aring;' scene=''>
+== Structural highlights ==
-==About this Structure==
+<table><tr><td colspan='2'>[[1e9w]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptomyces_azureus Streptomyces azureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1E9W OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1E9W FirstGlance]. <br>
-E9W is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Streptomyces_azureus Streptomyces azureus] with TZO, TZB, TZO, QUA and XBB as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1E9W OCA].
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.02&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BB9:(2Z)-2-AMINO-3-SULFANYLPROP-2-ENOIC+ACID'>BB9</scene>, <scene name='pdbligand=DBU:(2Z)-2-AMINOBUT-2-ENOIC+ACID'>DBU</scene>, <scene name='pdbligand=DCY:D-CYSTEINE'>DCY</scene>, <scene name='pdbligand=DHA:2-AMINO-ACRYLIC+ACID'>DHA</scene>, <scene name='pdbligand=MH6:3-HYDROXY-2-IMINOPROPANOIC+ACID'>MH6</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene>, <scene name='pdbligand=PRD_000223:THIOSTREPTON'>PRD_000223</scene>, <scene name='pdbligand=QUA:8-HYDROXY-4-(1-HYDROXYETHYL)QUINOLINE-2-CARBOXYLIC+ACID'>QUA</scene>, <scene name='pdbligand=TS9:(2S,3S,4R)-2-AMINO-3,4-DIHYDROXY-3-METHYLPENTANOIC+ACID'>TS9</scene></td></tr>
-==Reference==
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1e9w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1e9w OCA], [https://pdbe.org/1e9w PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1e9w RCSB], [https://www.ebi.ac.uk/pdbsum/1e9w PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1e9w ProSAT]</span></td></tr>
-Structure of the macrocycle thiostrepton solved using the anomalous dispersion contribution of sulfur., Bond CS, Shaw MP, Alphey MS, Hunter WN, Acta Crystallogr D Biol Crystallogr. 2001 May;57(Pt 5):755-8. Epub 2001, Apr 24. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=11320328 11320328]
+</table>
-[[Category: Single protein]]
+== Function ==
+[https://www.uniprot.org/uniprot/THCL_STRAJ THCL_STRAJ] Has bacteriocidal activity. Inhibits bacterial protein biosynthesis by acting on the elongation factor Tu (EF-Tu) (By similarity).
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
 [[Category: Streptomyces azureus]]
-[[Category: Alphey, M.S.]]
+[[Category: Alphey MS]]
-[[Category: Bond, C.S.]]
+[[Category: Bond CS]]
-[[Category: Hunter, W.N.]]
+[[Category: Hunter WN]]
-[[Category: Shaw, M.P.]]
+[[Category: Shaw MP]]
-[[Category: QUA]]
-[[Category: TZB]]
-[[Category: TZO]]
-[[Category: XBB]]
-[[Category: antibiotic]]
-[[Category: ribosome]]
-[[Category: thioazole]]
-[[Category: translation]]
-''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Sat Nov 24 21:57:01 2007''