2pyc: Difference between revisions

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OCA

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-[[Image:2pyc.jpg|left|200px]]<br /><applet load="2pyc" size="450" color="white" frame="true" align="right" spinBox="true"
-caption="2pyc, resolution 1.50&Aring;" />
-'''Crystal structure of a monomeric phospholipase A2 from Russell's viper at 1.5A resolution'''<br />
-==About this Structure==
+==Crystal structure of a monomeric phospholipase A2 from Russell's viper at 1.5A resolution==
-PYC is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Daboia_russellii_pulchella Daboia russellii pulchella] with ACT, SO4 and CCN as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Phospholipase_A(2) Phospholipase A(2)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.4 3.1.1.4] Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2PYC OCA].
+<StructureSection load='2pyc' size='340' side='right'caption='[[2pyc]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
-[[Category: Daboia russellii pulchella]]
+== Structural highlights ==
-[[Category: Phospholipase A(2)]]
+<table><tr><td colspan='2'>[[2pyc]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Daboia_russelii_pulchella Daboia russelii pulchella]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PYC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2PYC FirstGlance]. <br>
-[[Category: Single protein]]
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5&#8491;</td></tr>
-[[Category: Betzel, C.]]
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CCN:ACETONITRILE'>CCN</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-[[Category: Kaur, P.]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2pyc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2pyc OCA], [https://pdbe.org/2pyc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2pyc RCSB], [https://www.ebi.ac.uk/pdbsum/2pyc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2pyc ProSAT]</span></td></tr>
-[[Category: Kumar, S.]]
+</table>
-[[Category: Sharma, S.]]
+== Function ==
-[[Category: Singh, N.]]
+[https://www.uniprot.org/uniprot/PA2B8_DABRR PA2B8_DABRR] Snake venom phospholipase A2 (PLA2) that shows weak neurotoxicity and medium anticoagulant effects by binding to factor Xa (F10) and inhibiting the prothrombinase activity (IC(50) is 130 nM) (PubMed:18062812). It also damages vital organs such as lung, liver and kidney, displays edema-inducing activities when injected into the foot pads of mice and induces necrosis of muscle cells when injected into the thigh muscle. Has a low enzymatic activity. PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides.<ref>PMID:18062812</ref> <ref>PMID:2115497</ref> <ref>PMID:8835338</ref>
-[[Category: Singh, T.P.]]
+== Evolutionary Conservation ==
-[[Category: ACT]]
+[[Image:Consurf_key_small.gif|200px|right]]
-[[Category: CCN]]
+Check<jmol>
-[[Category: SO4]]
+  <jmolCheckbox>
-[[Category: active site]]
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/py/2pyc_consurf.spt"</scriptWhenChecked>
-[[Category: toxin]]
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2pyc ConSurf].
+<div style="clear:both"></div>
-''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Wed Nov 21 13:44:05 2007''
+==See Also==
+*[[Phospholipase A2 3D structures|Phospholipase A2 3D structures]]
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Daboia russelii pulchella]]
+[[Category: Large Structures]]
+[[Category: Betzel C]]
+[[Category: Kaur P]]
+[[Category: Kumar S]]
+[[Category: Sharma S]]
+[[Category: Singh N]]
+[[Category: Singh TP]]