1pqc: Difference between revisions

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{{Seed}}
[[Image:1pqc.png|left|200px]]


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==HUMAN LXR BETA HORMONE RECEPTOR COMPLEXED WITH T0901317==
The line below this paragraph, containing "STRUCTURE_1pqc", creates the "Structure Box" on the page.
<StructureSection load='1pqc' size='340' side='right'caption='[[1pqc]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)  
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1pqc]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PQC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1PQC FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=444:N-(2,2,2-TRIFLUOROETHYL)-N-{4-[2,2,2-TRIFLUORO-1-HYDROXY-1-(TRIFLUOROMETHYL)ETHYL]PHENYL}BENZENESULFONAMIDE'>444</scene></td></tr>
{{STRUCTURE_1pqc| PDB=1pqc |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1pqc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pqc OCA], [https://pdbe.org/1pqc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1pqc RCSB], [https://www.ebi.ac.uk/pdbsum/1pqc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1pqc ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/NR1H2_HUMAN NR1H2_HUMAN] Orphan receptor. Binds preferentially to double-stranded oligonucleotide direct repeats having the consensus half-site sequence 5'-AGGTCA-3' and 4-nt spacing (DR-4). Regulates cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8 (By similarity).
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/pq/1pqc_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1pqc ConSurf].
<div style="clear:both"></div>


===HUMAN LXR BETA HORMONE RECEPTOR COMPLEXED WITH T0901317===
==See Also==
 
*[[Liver X receptor|Liver X receptor]]
 
__TOC__
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</StructureSection>
The line below this paragraph, {{ABSTRACT_PUBMED_12819202}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 12819202 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12819202}}
 
==About this Structure==
1PQC is a 4 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PQC OCA].
 
==Reference==
<ref group="xtra">PMID:12819202</ref><references group="xtra"/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Ahola, H.]]
[[Category: Large Structures]]
[[Category: Bonn, T.]]
[[Category: Ahola H]]
[[Category: Carlquist, M.]]
[[Category: Bonn T]]
[[Category: Farnegardh, M.]]
[[Category: Carlquist M]]
[[Category: Gustafsson, J A.]]
[[Category: Farnegardh M]]
[[Category: Ljunggren, J.]]
[[Category: Gustafsson J-A]]
[[Category: Sun, S.]]
[[Category: Ljunggren J]]
[[Category: Wilhelmsson, A.]]
[[Category: Sun S]]
[[Category: Lxrb+t0901317]]
[[Category: Wilhelmsson A]]
[[Category: Transcription regulation]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Apr  2 16:17:41 2009''

Latest revision as of 11:10, 14 February 2024

HUMAN LXR BETA HORMONE RECEPTOR COMPLEXED WITH T0901317HUMAN LXR BETA HORMONE RECEPTOR COMPLEXED WITH T0901317

Structural highlights

1pqc is a 4 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.8Å
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

NR1H2_HUMAN Orphan receptor. Binds preferentially to double-stranded oligonucleotide direct repeats having the consensus half-site sequence 5'-AGGTCA-3' and 4-nt spacing (DR-4). Regulates cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8 (By similarity).

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

1pqc, resolution 2.80Å

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